Tricomponent Amphiphilic Poly(oligo(ethylene glycol) methacrylate) Brush-Grafted Poly(lactic acid): Synthesis, Nanoparticle Formation, and In Vitro Uptake and Release of Hydrophobic Dyes,Macromolecules

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Tricomponent Amphiphilic Poly(oligo(ethylene glycol) methacrylate) Brush-Grafted Poly(lactic acid): Synthesis, Nanoparticle Formation, and In Vitro Uptake and Release of Hydrophobic Dyes
Macromolecules ( IF 5.1 ) Pub Date : 2020-05-15 , DOI: 10.1021/acs.macromol.9b02467
Pranav P. Kalelkar ₁ , David M. Collard ₁

Affiliation

Tricomponent amphiphilic brush-grafted copolymers of poly(lactic acid)-graft-poly(oligo(ethylene glycol) methacrylate) (PLA-g-POEGMA) were prepared by atom-transfer radical polymerization (ATRP) of oligo(ethylene glycol) methacrylate (OEGMA) macromer using brominated poly(lactic acid) (Br-PLA) as a multisite macroinitiator. Br-PLA was prepared by free radical bromination of poly(lactic acid) (PLA) with N-bromosuccinimide (NBS). The amphiphilic copolymer, PLA-g-POEGMA, self-assembled to form sub-100 nm nanoparticles in aqueous solution. We report the uptake and release of hydrophobic dyes by the nanoparticles in buffer and in the presence of serum proteins and the low toxicity toward mammalian cells.

中文翻译：

三组分两亲性聚（低聚（甲基丙烯酸乙二醇酯）刷接的聚乳酸）：合成，纳米粒子形成以及疏水性染料的体外吸收和释放

聚（乳酸）-接枝-聚（低聚（乙二醇）甲基丙烯酸甲酯）（PLA- g- POEGMA）的三组分两亲刷接枝共聚物是通过低聚（乙二醇）甲基丙烯酸酯（ATRP）的原子转移自由基聚合（ATRP）制备的（ OEGMA）大分子单体，使用溴化聚乳酸（Br-PLA）作为多位大分子引发剂。Br-PLA是通过将N-溴代琥珀酰亚胺（NBS）自由基溴化聚乳酸（PLA）来制备的。两亲共聚物PLA- g -POEGMA在水溶液中自组装形成低于100 nm的纳米颗粒。我们报告纳米颗粒在缓冲液中和存在血清蛋白的存在下对疏水性染料的吸收和释放以及对哺乳动物细胞的低毒性。

更新日期：2020-05-15

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