Reactive oxygen species-mediated tumor chemodynamic therapy and photodynamic therapy have captured extensive attention in practical cancer combination therapies. However, the severe treatment conditions and the hypoxic microenvironment of solid tumors significantly limit the efficacy of these therapies. This work demonstrates the design and fabrication of a multifunctional persistent luminescence nanoplatform (PHFI, refers to PLNP-HSA-Fe³⁺-IR780) for cancer multimodal imaging and effective photoenhanced combination therapy. The near-infrared-emitted persistent luminescence nanoparticles (PLNP) was modified with human serum albumin (HSA) combined with an IR780 probe and Fe³⁺. The synthesized PHFI possesses high longitudinal relaxivity, obvious photoacoustic contrast signals, and long-lasting persistent luminescence, indicating that PHFI can be used for cancer magnetic resonance imaging, photoacoustic imaging, and persistent luminescence multimodal imaging. PHFI shows intrinsic photoenhanced Fenton-like catalytic activities as well as photodynamic and photothermal effects and thereby can effectively overcome severe treatment conditions for killing tumor cells. It is worth noting that PHFI serving as a rechargeable internal light source for photoenhanced combination therapy was first disclosed. We believe that our work shows the great potential of PHFI for cancer theranostics and will advance the development of PLNP-based nanoplatforms in tumor catalytic therapy.

中文翻译：

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具有Fenton类催化活性的持久发光纳米平台用于肿瘤多模态成像和光增强组合疗法。

活性氧介导的肿瘤化学动力疗法和光动力疗法在实际的癌症联合疗法中引起了广泛的关注。但是，严重的治疗条件和实体瘤的低氧微环境明显限制了这些疗法的疗效。这项工作演示了用于癌症多峰成像和有效光增强联合治疗的多功能持久发光纳米平台（PHFI，指PLNP-HSA-Fe ³⁺ -IR780）的设计和制造。用人血清白蛋白（HSA）结合IR780探针和Fe ³⁺修饰近红外发射的持久发光纳米粒子（PLNP）。。合成的PHFI具有较高的纵向弛豫度，明显的光声对比信号和持久的持久发光，表明PHFI可用于癌症磁共振成像，光声成像和持久发光多峰成像。PHFI显示出固有的光增强Fenton样催化活性以及光动力和光热效应，因此可以有效克服苛刻的治疗条件来杀死肿瘤细胞。值得注意的是，首先公开了用作光增强组合疗法的可充电内部光源的PHFI。我们相信我们的工作显示了PHFI在癌症治疗学上的巨大潜力，并将推动基于PLNP的纳米平台在肿瘤催化治疗中的发展。