Synthesis of Double Hydrophilic Block Copolymers Poly(2-oxazoline-b-ethylenimine) in a Two-Step Procedure,ACS Applied Polymer Materials

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Synthesis of Double Hydrophilic Block Copolymers Poly(2-oxazoline-b-ethylenimine) in a Two-Step Procedure
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-05-14 , DOI: 10.1021/acsapm.0c00308
Gwendoline Delecourt ₁ , Laetitia Plet ₁ , Véronique Bennevault _{1,

2} , Philippe Guégan ₁

Affiliation

The synthesis of double hydrophilic block copolymers (DHBCs) containing a polyethylenimine (PEI) and a poly(2-alkyl-2-oxazoline) in two steps was investigated in this study. First, well-defined copolymers of poly(2-methyl-2-oxazoline)-b-poly(2-ethyl-2-oxazoline) (PMeOx-b-PEtOx) and poly(2-isopropyl-2-oxazoline)-b-poly(2-methyl-2-oxazoline) (PiPrOx-b-PMeOx) were synthesized. Then, their thermoresponsive properties were analyzed to obtain a selective hydrolysis of the PMeOx block. Concerning the PMeOx-b-PEtOx copolymers, no phase transiton was witnessed, and a selectivity appeared but was quite low regardless of the copolymer composition tested, while for the PiPrOx-b-PMeOx copolymers, a complete selective hydrolysis was achieved, allowing the synthesis of PiPrOx-b-PEI DHBCs due to micelles formations in the reactive media at high temperature. Thus, for different PiPrOx-b-PMeOx with varying composition, a MeOx unit hydrolysis degree higher than 90% was obtained with nearly no hydrolysis of the PiPrOx block, providing block copolymers suitable for gene transfer experiments. The reproducibility of the reaction was also demonstrated.

中文翻译：

两步合成双亲水嵌段共聚物聚（2-恶唑啉-b-亚乙基亚胺）

本研究研究了分两个步骤合成包含聚乙烯亚胺（PEI）和聚（2-烷基-2-恶唑啉）的双亲水嵌段共聚物（DHBC）。首先，聚（2-甲基-2-恶唑啉）-b-聚（2-乙基-2-恶唑啉）（PMeOx- b -PEtOx）和聚（2-异丙基-2-恶唑啉）-b的定义明确的共聚物合成了-聚（2-甲基-2-恶唑啉）（PiPrOx- b- PMeOx）。然后，分析它们的热响应性能以获得PMeOx嵌段的选择性水解。关于PMeOx- b -PEtOx共聚物，没有观察到相转移，并且无论测试的共聚物组成如何，选择性均出现，但选择性非常低，而对于PiPrOx- b-PMeOx共聚物可实现完全的选择性水解，由于高温下在反应介质中形成胶束，因此可以合成PiPrOx- b -PEI DHBC。因此，对于具有变化组成的不同PiPrOx- b- PMeOx，获得了高于90％的MeOx单元水解度，而几乎没有PiPrOx嵌段的水解，提供了适合基因转移实验的嵌段共聚物。还证明了反应的可重复性。

更新日期：2020-07-10

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