双硫仑治疗使肥胖小鼠的体重正常化。,Cell Metabolism

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双硫仑治疗使肥胖小鼠的体重正常化。
Cell Metabolism ( IF 27.7 ) Pub Date : 2020-05-14 , DOI: 10.1016/j.cmet.2020.04.019
Michel Bernier ₁ , Sarah J Mitchell ₁ , Devin Wahl ₂ , Antonio Diaz ₃ , Abhishek Singh ₄ , Wonhyo Seo ₅ , Mingy Wang ₆ , Ahmed Ali ₁ , Tamzin Kaiser ₁ , Nathan L Price ₄ , Miguel A Aon ₇ , Eun-Young Kim ₈ , Michael A Petr ₁ , Huan Cai ₉ , Alessa Warren ₁₀ , Clara Di Germanio ₁ , Andrea Di Francesco ₁ , Ken Fishbein ₉ , Vince Guiterrez ₁ , Dylan Harney ₁₁ , Yen Chin Koay ₁₂ , John Mach ₁₃ , Ignacio Navas Enamorado ₁ , Tamara Pulpitel ₁₄ , Yushi Wang ₆ , Jing Zhang ₆ , Li Zhang ₆ , Richard G Spencer ₉ , Kevin G Becker ₁₅ , Josephine M Egan ₉ , Edward G Lakatta ₆ , John O'Sullivan ₁₂ , Mark Larance ₁₁ , David G LeCouteur ₁₄ , Victoria C Cogger ₁₄ , Bin Gao ₅ , Carlos Fernandez-Hernando ₄ , Ana Maria Cuervo ₃ , Rafael de Cabo ₁

Affiliation

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; Ageing and Alzheimer's Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord, NSW 2139, Australia.
Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY 10461, USA.
Vascular Biology and Therapeutics Program, Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA; Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA; Functional Genomics Research Center, KRIBB, Daejeon 305-806, Republic of Korea.
Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Ageing and Alzheimer's Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord, NSW 2139, Australia.
Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; Heart Research Institute, The University of Sydney, Sydney, NSW 2042, Australia.
Kolling Institute of Medical Research and Sydney Medical School, University of Sydney, Sydney, NSW 2065, Australia.
Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; Ageing and Alzheimer's Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord, NSW 2139, Australia.
Laboratory of Genetics, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.

肥胖是一个首要的公共卫生问题，迫切需要一种安全治疗肥胖的分子。双硫仑（商业上称为 Antabuse）是一种 FDA 批准的慢性酒精成瘾治疗方法，具有抗炎特性，有助于预防某些类型的癌症。在这里，我们表明双硫仑治疗在小鼠中阻止了体重增加并消除了致肥胖饮食对胰岛素反应性的不利影响，同时减轻了肝脏脂肪变性和胰岛肥大。此外，双硫仑治疗逆转了中年小鼠饮食诱导的肥胖和代谢功能障碍。喂养效率的降低和能量消耗的增加与响应长期双硫仑治疗的体重调节有关。在服用双硫仑的大鼠中也观察到脂肪组织的减少和肝脏开窗的增加。鉴于啮齿类动物的有效抗致肥胖作用，在临床中重新利用双硫仑可能代表治疗肥胖及其代谢合并症的新策略。

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更新日期：2020-05-14

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