当前位置：
X-MOL 学术
›
Nano Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Mimetic Heat Shock Protein Mediated Immune Process to Enhance Cancer Immunotherapy.
Nano Letters ( IF 9.6 ) Pub Date : 2020-05-13 , DOI: 10.1021/acs.nanolett.0c01230 Xue Li 1 , Xiaoyao Cai 2 , Zhanzhan Zhang 1 , Yuxun Ding 1 , Rujiang Ma 1 , Fan Huang 3 , Yang Liu 1 , Jianfeng Liu 3 , Linqi Shi 1
Nano Letters ( IF 9.6 ) Pub Date : 2020-05-13 , DOI: 10.1021/acs.nanolett.0c01230 Xue Li 1 , Xiaoyao Cai 2 , Zhanzhan Zhang 1 , Yuxun Ding 1 , Rujiang Ma 1 , Fan Huang 3 , Yang Liu 1 , Jianfeng Liu 3 , Linqi Shi 1
Affiliation
|
Inspired by heat shock proteins (HSPs), a self-assembly nanochaperone (nChap) is developed as a novel nanovaccine for boosting antitumor immune responses. Taking advantage of HSP-like microdomains and surface-decorated mannose, this nChap can efficiently capture antigens and ferry them into the dendritic cells (DCs). Subsequently, the nChap can blast lysosomes by transforming the structure and property of surface microdomains, thereby promoting antigen escape and enhancing their cross-presentation in cytoplasm. As a result, the nChap-based nanovaccine can elicit both CD4+ and CD8+ T cell-based immune responses and shows an excellent preventive effect on melanoma. Further combination of the nanovaccine with antiprogrammed death-1 (anti-PD-1) checkpoint blockade offers effective inhibition on the growth of already-established melanoma. Therefore, this nC ap-based nanovaccine provides a simple and robust strategy in mimicking HSPs to realize structure-assisted antigen capture, surface-receptor-mediated DC internalization, and both activation of humoral immunity and cellular immunity, promising for efficient cancer immunotherapy.
中文翻译：
模拟热休克蛋白介导的免疫过程可增强癌症免疫治疗。
受热休克蛋白（HSPs）的启发，自组装纳米伴侣（nChap）被开发为一种新型纳米疫苗，可增强抗肿瘤免疫反应。利用类似HSP的微区和表面修饰的甘露糖，该nChap可以有效捕获抗原并将其运送到树突状细胞（DC）中。随后，nChap可以通过改变表面微区的结构和特性来爆炸溶酶体，从而促进抗原逃逸并增强其在细胞质中的交叉呈递。结果，基于nChap的纳米疫苗可引发基于CD4 +和CD8 + T细胞的免疫反应，并对黑色素瘤显示出极好的预防作用。纳米疫苗与抗程序性死亡1（抗PD-1）检查点封锁的进一步组合可有效抑制已经建立的黑色素瘤的生长。因此，
更新日期：2020-05-13
中文翻译：
模拟热休克蛋白介导的免疫过程可增强癌症免疫治疗。
受热休克蛋白（HSPs）的启发，自组装纳米伴侣（nChap）被开发为一种新型纳米疫苗，可增强抗肿瘤免疫反应。利用类似HSP的微区和表面修饰的甘露糖，该nChap可以有效捕获抗原并将其运送到树突状细胞（DC）中。随后，nChap可以通过改变表面微区的结构和特性来爆炸溶酶体，从而促进抗原逃逸并增强其在细胞质中的交叉呈递。结果，基于nChap的纳米疫苗可引发基于CD4 +和CD8 + T细胞的免疫反应，并对黑色素瘤显示出极好的预防作用。纳米疫苗与抗程序性死亡1（抗PD-1）检查点封锁的进一步组合可有效抑制已经建立的黑色素瘤的生长。因此，
京公网安备 11010802027423号