Micro-/Nanotopography on Bioresorbable Zinc Dictates Cytocompatibility, Bone Cell Differentiation, and Macrophage Polarization.,Nano Letters

当前位置： X-MOL 学术 › Nano Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Micro-/Nanotopography on Bioresorbable Zinc Dictates Cytocompatibility, Bone Cell Differentiation, and Macrophage Polarization.
Nano Letters ( IF 9.6 ) Pub Date : 2020-05-13 , DOI: 10.1021/acs.nanolett.0c01448
Irsalan Cockerill _{1,

2} , Yingchao Su ₃ , Ji Hyung Lee ₂ , Diana Berman ₂ , Marcus L Young ₂ , Yufeng Zheng ₄ , Donghui Zhu ₃

Affiliation

Bioresorbable metals are quickly advancing in the field of regenerative medicine for their promises of tissue restoration without adverse consequences from their lifelong presence. Zn has recently risen to the top of bioresorbable metals with great potential as a medical implant. However, cell adhesion and colonization on the Zn substrate surface remains challenging, which could damper interfacial tissue–implant integration. Inspired by the fact that surface topography can regulate cell function and fate, we hypothesize that topography on bioresorbable Zn can dictate material biocompatibility, cell differentiation, and immunomodulation. To verify this, surface-engineered Zn plates with nano-, submicro-, and microtopographies were systematically investigated. The microscale topography exhibited increased adhesion, pronounced self-renewal, and enhanced osteogenic differentiation of bone cells as well as less macrophage inflammatory polarization, reduced platelet adhesion, and better hemocompatibility. Thus, surface topography could be a viable strategy to enhance bioresorbable Zn’s biocompatibility and integration with surrounding tissues while reducing inflammation.

中文翻译：

生物可吸收锌的微观/纳米形貌决定了细胞相容性，骨细胞分化和巨噬细胞极化。

生物可吸收金属因其有望组织修复而不会因其终身存在而带来不利后果，因此在再生医学领域迅速发展。锌最近已上升到生物可吸收金属的顶部，具有作为医疗植入物的巨大潜力。但是，细胞在锌基质表面上的粘附和定植仍然具有挑战性，这可能会抑制界面组织与植入物的整合。受表面形貌可调节细胞功能和命运的事实启发，我们假设生物可吸收锌的形貌可决定材料的生物相容性，细胞分化和免疫调节。为了验证这一点，系统地研究了具有纳米，亚微和微形貌的表面工程锌板。微观形貌显示出增加的附着力，明显的自我更新，并增强了骨细胞的成骨分化能力，并减少了巨噬细胞的炎症极化，降低了血小板的粘附性，并具有更好的血液相容性。因此，表面形貌可能是增强生物可吸收锌的生物相容性和与周围组织整合同时减少炎症的可行策略。

更新日期：2020-05-13

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南