Diaza-Crown Ether-Bridged Chiral Diphosphoramidite Ligands: Synthesis and Applications in Asymmetric Catalysis.,The Journal of Organic Chemistry

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Diaza-Crown Ether-Bridged Chiral Diphosphoramidite Ligands: Synthesis and Applications in Asymmetric Catalysis.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-05-13 , DOI: 10.1021/acs.joc.0c00223
Yier Luo _{1,

2} , Guanghui Ouyang ₁ , Yuping Tang _{1,

2} , Yan-Mei He ₁ , Qing-Hua Fan _{1,

2}

Affiliation

A small library of diaza-crown ether-bridged chiral diphosphoramidite ligands was prepared. In the rhodium-catalyzed asymmetric hydrogenation and hydroformylation reactions, these ligands exhibited distinct properties in catalytic activity and/or enantioselectivity. Hydrogenated products with opposite absolute configurations could be obtained in high yields with excellent ee values by utilizing (S,S)-L1 and (S,S)-L3, respectively. Meanwhile, the addition of alkali metal cations caused variations in catalytic outcomes, showing the supramolecular tunability of these Rh/diphosphoramidite catalytic systems.

中文翻译：

Diaza冠醚桥连的手性二亚磷酰胺基配体：合成及其在不对称催化中的应用。

制备了小的二氮杂-冠醚桥连的手性二亚磷酰胺配体文库。在铑催化的不对称氢化和加氢甲酰化反应中，这些配体在催化活性和/或对映选择性方面表现出不同的性质。氢化产物具有相反绝对构型可以以高收率和优异的EE值通过利用获得（小号，小号- ）L1和（小号，小号） - L3，分别。同时，碱金属阳离子的添加导致催化结果的变化，显示出这些Rh /二亚磷酰胺催化剂的超分子可调谐性。

更新日期：2020-06-19

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