Sustainable Chemistry and Pharmacy ( IF 5.5 ) Pub Date : 2020-05-12 , DOI: 10.1016/j.scp.2020.100265 Singamsetty Harikrishna , Alice R. Robert , Himavathi Ganja , Suresh Maddila , Sreekantha B. Jonnalagadda
An efficient three‐component condensation reaction of aromatic aldehydes, 1,3-cyclohexanedione and 5-amino-3-methyl-1-phenylpyrazole in the presence of 2.5% Mn doped MWCNT nanoparticles as a heterogeneous, eco-friendly, recyclable and competent catalyst provided the subsequent quinoline derivatives in excellent yields (92–98%) under green solvent condition in very short reaction times. The prepared catalyst was characterized using different analytical techniques such as PXRD, N2 adsorption–desorption, FESEM, EDX and TEM. This protocol deals various benefits such as simple operation, easy handling, inexpensive, short reaction times, absence of toxic solvents, excellent yields, and avoidance of tedious workup. Additionally, the catalyst is easily separated and reused up to eight cycles without any significant loss of catalytic activity.
中文翻译:
一种绿色,易回收的Mn 3 O 4 / MWCNT纳米催化剂,用于通过一锅多组分反应合成喹啉
在2.5%Mn掺杂的MWCNT纳米颗粒存在下,芳香醛,1,3-环己二酮和5-氨基-3-甲基-1-苯基吡唑的高效三组分缩合反应作为非均相,生态友好,可回收和有效的催化剂在绿色溶剂条件下以非常短的反应时间提供了后续的喹啉衍生物,收率极高(92-98%)。使用不同的分析技术(如PXRD,N 2)对制备的催化剂进行表征吸附-解吸,FESEM,EDX和TEM。该方案具有多种优点,例如操作简单,易于操作,价格便宜,反应时间短,无毒溶剂,产率高以及避免繁琐的后处理。另外,该催化剂易于分离并重复使用多达八个循环,而没有任何明显的催化活性损失。