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Self-Healing Injectable Polymer Hydrogel via Dynamic Thiol-Alkynone Double Addition Cross-Links.
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-05-12 , DOI: 10.1021/acsmacrolett.0c00241 Bowen Fan 1 , Kai Zhang 1 , Qian Liu 1 , Rienk Eelkema 1
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-05-12 , DOI: 10.1021/acsmacrolett.0c00241 Bowen Fan 1 , Kai Zhang 1 , Qian Liu 1 , Rienk Eelkema 1
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Introduction of dynamic thiol-alkynone double addition cross-links in a polymer network enable the formation of a self-healing injectable polymer hydrogel. A four-arm polyethylene glycol (PEG) tetra-thiol star polymer is cross-linked by a small molecule alkynone via the thiol-alkynone double adduct to generate a hydrogel network under ambient aqueous conditions (buffer pH = 7.4 or 8.2, room temperature). The mechanical properties of these hydrogels can be easily tuned by varying the concentration of polymer precursors. Through the dynamic thiol-alkynone double addition cross-link, these hydrogels are self-healing and shear thinning, as demonstrated by rheological measurements, macroscopic self-healing, and injection tests. These hydrogels can be injected through a 20G syringe needle and recover after extrusion. In addition, good cytocompatibility of these hydrogels is confirmed by cytotoxicity test. This work shows the application of the thiol-alkynone double addition dynamic covalent chemistry in the straightforward preparation of self-healing injectable hydrogels, which may find future biomedical applications such as tissue engineering and drug delivery.
中文翻译：
通过动态硫醇-炔酮双加成交联的自修复可注射聚合物水凝胶。
在聚合物网络中引入动态硫醇-炔酮双加成交联能够形成自修复的可注射聚合物水凝胶。四臂聚乙二醇 (PEG) 四硫醇星形聚合物与小分子炔酮通过硫醇-炔酮双加合物交联，在环境水性条件下（缓冲液 pH = 7.4 或 8.2，室温）生成水凝胶网络。这些水凝胶的机械性能可以通过改变聚合物前体的浓度来轻松调节。通过动态硫醇-炔酮双加成交联，这些水凝胶具有自修复和剪切稀化功能，如流变测量、宏观自修复和注射测试所证明的那样。这些水凝胶可以通过20G注射器针头注射，并在挤出后恢复。此外，细胞毒性测试证实了这些水凝胶具有良好的细胞相容性。这项工作展示了硫醇-炔酮双加成动态共价化学在直接制备自修复可注射水凝胶中的应用，这可能会在组织工程和药物输送等未来生物医学应用中找到应用。
更新日期：2020-05-12
中文翻译：
通过动态硫醇-炔酮双加成交联的自修复可注射聚合物水凝胶。
在聚合物网络中引入动态硫醇-炔酮双加成交联能够形成自修复的可注射聚合物水凝胶。四臂聚乙二醇 (PEG) 四硫醇星形聚合物与小分子炔酮通过硫醇-炔酮双加合物交联，在环境水性条件下（缓冲液 pH = 7.4 或 8.2，室温）生成水凝胶网络。这些水凝胶的机械性能可以通过改变聚合物前体的浓度来轻松调节。通过动态硫醇-炔酮双加成交联，这些水凝胶具有自修复和剪切稀化功能，如流变测量、宏观自修复和注射测试所证明的那样。这些水凝胶可以通过20G注射器针头注射，并在挤出后恢复。此外，细胞毒性测试证实了这些水凝胶具有良好的细胞相容性。这项工作展示了硫醇-炔酮双加成动态共价化学在直接制备自修复可注射水凝胶中的应用，这可能会在组织工程和药物输送等未来生物医学应用中找到应用。
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