N‐Heterocyclic Carbene Copper(I) Complex Catalyzed Coupling of (Hetero)aryl Chlorides and Nitrogen Heterocycles: Highly Efficient Catalytic System,Chinese Journal of Chemistry

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N‐Heterocyclic Carbene Copper(I) Complex Catalyzed Coupling of (Hetero)aryl Chlorides and Nitrogen Heterocycles: Highly Efficient Catalytic System
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-05-11 , DOI: 10.1002/cjoc.201900461
Mengyao Zhang ₁ , Yingying Zhang ₁ , Huixin Zhang ₁ , Yongfei Zeng ₁ , Guiyan Liu ₁

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A highly efficient catalytic system for the N‐arylation reactions of (hetero)aryl chlorides and nitrogen heterocycles with a copper(I) complex containing a 1,10‐phenanthroline analogue N‐heterocyclic carbene (NHC) has been reported. The complex was characterized by ¹H NMR and ¹³C NMR spectroscopy and elemental analysis, and its structure was determined by single‐crystal X‐ray diffraction. The NHC‐copper(I) complex was employed as pre‐catalyst for Ullmann type N‐arylation reactions of (hetero)aryl chlorides with various azoles. A variety of hindered and functionalized azoles and (hetero)aryl chlorides were transformed in good to excellent yields.

中文翻译：

N-杂环碳烯铜（I）络合物催化（杂）芳基氯化物与氮杂环的偶联：高效催化体系

已经报道了一种高效的催化体系，用于（杂）芳基氯和氮杂环与含1,10-菲咯啉类似物N-杂环卡宾（NHC）的铜（I）配合物的N-芳基化反应。该复合物通过¹ H NMR和¹³ C NMR光谱学和元素分析进行表征，并通过单晶X射线衍射确定其结构。NHC-铜（I）络合物被用作（杂）芳基氯与各种唑类的Ullmann型N-芳基化反应的前催化剂。各种受阻和官能化的吡咯和（杂）芳基氯化物均以良好的转化率获得了优异的收率。

更新日期：2020-05-11

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