沸石咪唑酸盐骨架在癌症治疗，抗菌活性和生物矿化中的研究进展与展望。,Advanced Healthcare Materials

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沸石咪唑酸盐骨架在癌症治疗，抗菌活性和生物矿化中的研究进展与展望。
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-05-07 , DOI: 10.1002/adhm.202000248
Aziz Maleki _{1,

2} , Mohammad-Ali Shahbazi _{1,

3} , Vajiheh Alinezhad ₁ , Hélder A Santos _{3,

4}

Affiliation

作为金属有机骨架（MOF）的亚家族，沸石咪唑酸酯骨架（ZIF）的逐步发展及其独特的功能（包括可调的孔径，大的表面积，高的热稳定性和生物降解性/生物相容性）使其具有吸引力在生物医学领域，尤其是在药物输送和生物矿化应用中。ZIF的高孔隙率使它们有机会封装大量治疗药物，蛋白质，成像货物或将它们组合使用，以构建具有治疗和成像功能相结合的高级多功能药物递送系统（DDS）。这篇综述总结了基于ZIF的纳米系统的设计和制造的最新策略及其在生物医学领域的探索。第一，讨论了调节ZIF的粒径，功能和形态的最新进展，这对实现优化的治疗/热疗纳米系统非常重要。其次，研究了ZIF纳米载体在装载各种货物中的最新趋势，包括抗癌药，抗生素药物，酶，蛋白质，光敏剂以及成像和光热剂，以了解如何设计多功能DDS。基于ZIF纳米粒子的药物可治疗各种疾病，例如癌症和感染。最后，讨论了基于ZIF的纳米药物的未来研究方向和应用前景。ZIF纳米载体在装载各种货物（包括抗癌药，抗生素药物，酶，蛋白质，光敏剂以及成像和光热剂）中的应用的最新趋势，以了解如何设计基于DIF的多功能DDS。 ZIF纳米粒子可治疗各种疾病，例如癌症和感染。最后，讨论了基于ZIF的纳米药物的未来研究方向和应用前景。ZIF纳米载体在装载各种货物（包括抗癌药，抗生素药物，酶，蛋白质，光敏剂以及成像和光热剂）中的最新应用趋势，旨在了解如何根据以下内容设计多功能DDS： ZIF纳米粒子可治疗各种疾病，例如癌症和感染。最后，讨论了基于ZIF的纳米药物的未来研究方向和应用前景。例如癌症和感染。最后，讨论了基于ZIF的纳米药物的未来研究方向和应用前景。例如癌症和感染。最后，讨论了基于ZIF的纳米药物的未来研究方向和应用前景。

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The Progress and Prospect of Zeolitic Imidazolate Frameworks in Cancer Therapy, Antibacterial Activity, and Biomineralization.

The progressive development of zeolitic imidazolate frameworks (ZIFs), as a subfamily of metal‐organic frameworks (MOFs), and their unique features, including tunable pore size, large surface area, high thermal stability, and biodegradability/biocompatibility, have made them attractive in the field of biomedicine, especially for drug delivery and biomineralization applications. The high porosity of ZIFs gives them the opportunity for encapsulating a high amount of therapeutic drugs, proteins, imaging cargos, or a combination of them to construct advanced multifunctional drug delivery systems (DDSs) with combined therapeutic and imaging capabilities. This review summarizes recent strategies on the design and fabrication of ZIF‐based nansystems and their exploration in the biomedical field. First, recent developments for the adjustment of particle size, functionality, and morphology of ZIFs are discussed, which are important for achieving optimized therapeutic/theranostic nanosystems. Second, recent trends on the application of ZIF nanocarriers for the loading of diverse cargos, including anticancer medicines, antibiotic drugs, enzymes, proteins, photosensitizers, as well as imaging and photothermal agents, are investigated in order to understand how multifunctional DDSs can be designed based on the ZIF nanoparticles to treat different diseases, such as cancer and infection. Finally, prospects on the future research direction and applications of ZIF‐based nanomedicines are discussed.

更新日期：2020-06-24

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