Endothelial Progenitor Cell-Derived Extracellular Vesicles: A Novel Candidate for Regenerative Medicine and Disease Treatment.,Advanced Healthcare Materials

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Endothelial Progenitor Cell-Derived Extracellular Vesicles: A Novel Candidate for Regenerative Medicine and Disease Treatment.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-05-06 , DOI: 10.1002/adhm.202000255
Zheng Xing ₁ , Chen Zhao ₂ , Haifeng Liu _{1,

3} , Yubo Fan _{1,

3,

4}

Affiliation

Extracellular vesicles (EVs) are a heterogeneous group of membranous structures, which can be secreted by most cell types. As a product of paracrine secretion, EVs are considered to be a regulatory mediator for intercellular communication. There are many bioactive cargos in EVs, such as proteins, lipids, and nucleic acids. As the precursor cell of vascular endothelial cells (ECs), endothelial progenitor cells (EPCs) are first discovered in peripheral blood. With the development of studies about the functions of EPCs, an increasing number of researchers focus on EPC‐derived EVs (EPC‐EVs). EPC‐EVs exert key functions for promoting angiogenesis in regenerative medicine and show significant therapeutic effects on a variety of diseases such as circulatory diseases, kidney diseases, diabetes, bone diseases, and tissue/organ damages. This article reviews the current knowledge on the role of EPC‐EVs in regenerative medicine and disease treatment, discussing the main challenges and future directions in this field.

中文翻译：

内皮祖细胞衍生的细胞外囊泡：再生医学和疾病治疗的新型候选人。

细胞外囊泡（EVs）是膜结构的异质性组，大多数细胞类型都可以分泌。作为旁分泌分泌的产物，电动汽车被认为是细胞间通讯的调节介体。电动汽车中有许多具有生物活性的货物，例如蛋白质，脂质和核酸。作为血管内皮细胞（EC）的前体细胞，内皮祖细胞（EPC）首先在外周血中发现。随着对EPC功能的研究的发展，越来越多的研究人员开始关注EPC衍生的电动汽车（EPC-EV）。EPC-EV在再生医学中发挥促进血管生成的关键功能，并对循环系统疾病，肾脏疾病，糖尿病，骨骼疾病和组织/器官损伤等多种疾病显示出显着的治疗效果。

更新日期：2020-06-24

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