An Aquafoldmer-Based Aquaporin-Like Synthetic Water Channel,Journal of the American Chemical Society

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An Aquafoldmer-Based Aquaporin-Like Synthetic Water Channel
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-05-06 , DOI: 10.1021/jacs.0c02013
Jie Shen ₁ , Ruijuan Ye ₂ , Alyssa Romanies ₃ , Arundhati Roy ₁ , Feng Chen ₁ , Changliang Ren ₁ , Zhiwei Liu ₃ , Huaqiang Zeng ₁

Affiliation

Synthetic water channels were developed with an aim to replace Aquaporins for possible uses in water purification, while concurrently retaining Aquaporins' ability to conduct highly selective superfast water transport. Among the currently available synthetic water channel systems, none possesses water transport properties that parallel those of Aquaporins. In this report, we present the first synthetic water channel system with intriguing Aquaproin-like features. Employing a "sticky end"-mediated molecular strategy for constructing abiotic water channels, we demonstrate that a 20% enlargement in angstrom-scale pore volume could effect a remarkable enhancement in macroscopic water transport profile by 15 folds. This gives rise to a powerful synthetic water channel able to transport water at a speed of ~ 3 x 109 H2O•s-1•channel-1 with high rejection of NaCl and KCl. This high water permeability, which is about 50% of Aquaporin Z's capacity, makes channel 1 the fastest among the existing synthetic water channels with high selectivity.

中文翻译：

基于 Aquafoldmer 的类水通道蛋白合成水通道

开发合成水通道的目的是取代水通道蛋白在水净化中的可能用途，同时保留水通道蛋白进行高选择性超快速水传输的能力。在目前可用的合成水通道系统中，没有一个具有与水通道蛋白平行的水传输特性。在本报告中，我们展示了第一个具有有趣的类似 Aquaproin 特征的合成水通道系统。采用“粘性末端”介导的分子策略构建非生物水通道，我们证明埃级孔隙体积增加 20% 可以显着增强宏观水传输剖面 15 倍。这产生了一个强大的合成水通道，能够以 ~ 3 x 109 H2O•s-1•channel-1 的速度传输水，并具有很高的 NaCl 和 KCl 排斥率。这种高透水率约为 Aquaporin Z 容量的 50%，使通道 1 成为现有的高选择性合成水通道中最快的通道。

更新日期：2020-05-06

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