Membrane-Assisted Antisolvent Crystallization: Interfacial Mass-Transfer Simulation and Multistage Process Control,Industrial & Engineering Chemistry Research

当前位置： X-MOL 学术 › Ind. Eng. Chem. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Membrane-Assisted Antisolvent Crystallization: Interfacial Mass-Transfer Simulation and Multistage Process Control
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2020-05-06 , DOI: 10.1021/acs.iecr.0c01645
Jin Li ₁ , Lei Sheng ₁ , Linghan Tuo ₁ , Wu Xiao ₁ , Xuehua Ruan ₁ , Xiaoming Yan ₁ , Gaohong He ₁ , Xiaobin Jiang ₁

Affiliation

Antisolvent crystallization is an important purification technology for the pharmaceutical and fine chemical industries. Herein, we investigated the mass-transfer mechanism of membrane-assisted antisolvent crystallization (MAAC) and developed a multistage operation to reinforce the manufacturing features of antisolvent crystallization. Computational fluid dynamics simulation results via a developed mathematics model and the experimental images via in situ detection technology jointly illustrated the advantages of MAAC for accurate mass-transfer control. Further, a three-stage MAAC process was investigated to reveal the process control performance. The diverse functional regions of multistage MAAC under different antisolvent addition strategies were then highlighted by manufacturing the crystal products with a narrow size distribution, a uniform aspect ratio, and the desired morphology. Multistage MAAC that intensifies the product capacity under a stable control is a promising direction for new-generation antisolvent crystallization.

中文翻译：

膜辅助反溶剂结晶：界面传质模拟和多阶段过程控制

反溶剂结晶是制药和精细化工行业的重要纯化技术。在本文中，我们研究了膜辅助抗溶剂结晶（MAAC）的传质机理，并开发了多阶段操作以增强抗溶剂结晶的制造特征。通过开发的数学模型进行的计算流体动力学模拟结果和通过原位检测技术得到的实验图像共同说明了MAAC进行精确传质控制的优势。此外，研究了三阶段MAAC过程以揭示过程控制性能。然后，通过制造具有窄尺寸分布的晶体产品，强调了在不同抗溶剂添加策略下多级MAAC的不同功能区域，均匀的长宽比和所需的形态。在稳定的控制下增强产品容量的多级MAAC是新一代抗溶剂结晶的有前途的方向。

更新日期：2020-05-06

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南