The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. This article reports the potential drug target and mechanism of action of Arbidol (umifenovir) to treat coronavirus disease 2019 (COVID-19). Molecular dynamics and structural analysis were used to show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impedes its trimerization, which is key for host cell adhesion and hijacking, indicating the potential of Arbidol to treat COVID-19. It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2.

中文翻译：

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Arbidol：一种潜在的抗病毒药物，可通过阻断刺突糖蛋白的三聚化来治疗 SARS-CoV-2。

严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 大流行是全球突发公共卫生事件，需要新的治疗方法。本文报道了阿比多尔（umifenovir）治疗 2019 冠状病毒病（COVID-19）的潜在药物靶点和作用机制。分子动力学和结构分析用于显示阿比朵尔如何靶向 SARS-CoV-2 刺突糖蛋白并阻止其三聚化，这是宿主细胞粘附和劫持的关键，表明阿比朵尔治疗 COVID-19 的潜力。希望对 Arbidol 的潜在药物靶点和作用机制的了解将有助于开发 SARS-CoV-2 的新疗法。