<br>关于薄荷醇血管作用的最新知识。,Frontiers in Physiology

当前位置： X-MOL 学术 › Front. Physiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

关于薄荷醇血管作用的最新知识。
Frontiers in Physiology ( IF 3.2 ) Pub Date : 2020-04-07 , DOI: 10.3389/fphys.2020.00298
Henrique Silva _{1,

2,

3,

4}

Affiliation

薄荷醇是一种单萜醇，因其独特的气味和风味而广泛用于多种食品和保健产品。几十年来，人们知道薄荷醇直接作用于内皮和血管平滑肌的脉管系统，最近的研究表明，它还可以通过感觉纤维引起间接血管反应。由于细胞靶标的多样性、信号通路之间的相互作用以及反应的可变性，薄荷醇血管作用的机制很复杂。薄荷醇可以引起体内不同血管区域的灌注增加或减少，这一观察值得进行批判性讨论。薄荷醇在体内的血管作用似乎取决于所分析的血管区域是直接用薄荷醇激发的还是位于应用部位的深处/远处。由于一氧化氮 (NO)、内皮源性超极化因子 (EDHF) 和感觉神经反应增加的复杂相互作用，薄荷醇可增加直接刺激的皮肤区域的灌注。在非诱发血管床中，薄荷醇减少灌注，这可能归因于热保存交感神经介导的血管收缩，尽管由于制剂乙醇导致组织蒸发热损失增加也可能发挥作用。越来越多的证据表明薄荷醇的几个细胞靶点与心血管疾病有关，例如高血压。因此，薄荷醇和药理相似的药物可以发挥重要的预防和治疗作用，值得进一步研究。

"点击查看英文标题和摘要"

Current Knowledge on the Vascular Effects of Menthol.

Menthol is a monoterpene alcohol, widely used in several food and healthcare products for its particular odor and flavor. For some decades, menthol has been known to act on the vasculature directly in the endothelium and vascular smooth muscle, with recent studies showing that it also evokes an indirect vascular response via sensory fibers. The mechanisms underlying menthol's vascular action are complex due to the diversity of cellular targets, to the interplay between signaling pathways and to the variability in terms of response. Menthol can evoke either a perfusion increase or decrease in vivo in different vascular territories, an observation that warrants a critical discussion. Menthol vascular actions in vivo seem to depend on whether the vascular territory under analysis has been directly provoked with menthol or is located deep/distant to the application site. Menthol increases perfusion of directly provoked skin regions due to a complex interplay of increased nitric oxide (NO), endothelium-derived hyperpolarization factors (EDHFs) and sensory nerve responses. In non-provoked vascular beds menthol decreases perfusion which might be attributed to heat-conservation sympathetically-mediated vasoconstriction, although an increase in tissue evaporative heat loss due the formulation ethanol may also play a role. There is increasing evidence that several of menthol's cellular targets are involved in cardiovascular diseases, such as hypertension. Thus menthol and pharmacologically-similar drugs can play important preventive and therapeutic roles, which merits further investigation.

更新日期：2020-04-07

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南