再次审查儿科白内障的ToRCH筛查：北印度三级护理中心的一项研究。,Indian Journal of Ophthalmology

当前位置： X-MOL 学术 › Indian J. Ophthalmol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

再次审查儿科白内障的ToRCH筛查：北印度三级护理中心的一项研究。
Indian Journal of Ophthalmology ( IF 2.1 ) Pub Date : 2020-05-01 , DOI: 10.4103/ijo.ijo_1141_19
Sushobhan Dasgupta ₁ , Tarannum Shakeel ₁ , Reshmi Chanda Roy ₁

Affiliation

目的：分析和报告儿童白内障中的ToRCH血清学筛查概况（弓形虫[TOX]，风疹[RV]，巨细胞病毒[CMV]和单纯疱疹病毒[HSV-I / II]）。方法：在这项前瞻性分析研究中，筛查了1,026名连续儿童，其中包括46名临床诊断为先天性（n = 26）和发育性白内障（n = 20）的儿童。排除创伤后和家族性白内障。依次对所有儿童的血清进行了定性和定量的抗ToRCH药物IgG / IgM抗体检测。结果：总体而言，在91.3％（42/46）儿童中报告了针对≥1ToRCH药剂的IgM / IgG血清阳性。在26.08％（12/46）儿童（九名先天性和三个发育性白内障；P = 0.18）中，报告有26.08％（12/46）儿童的IgM（±IgG）阳性（≥9 ），其中8.7％（4/46）儿童对≥2呈阳性代理商。最后，据报道有13％（6/46）的儿童血清学阳性（三名婴儿，三名> 1岁，P = 0.55；五名先天性和一名发育性白内障，P= 0.21）。无论是单独还是合并使用，RV均归因于IgM（±IgG）的大多数（50％； 6/12）和血清学阳性的儿童（50％； 3/6）。所有儿童均未出现HSV-II IgM阳性。实验室确认的先天性风疹综合症报告为4.3％（2/46）儿童。还报告了一名血清学阳性婴儿，其罕见的双侧持续性胎儿脉管系统并存。据报道，在67.4％（31/46）儿童中，CMV的IgG单独阳性率最高，而对RV不免疫的儿童为43.4％（20/46）。结论：当前的研究强调必须谨慎地解释小儿白内障的ToRCH筛查。解释应包括与临床相关性的串联定性和定量分析，以最大程度地减少诊断错误。对于可能对感染传播构成威胁的大龄儿童，临床医生也应保持警惕。

"点击查看英文标题和摘要"

ToRCH-screening in pediatric cataract revisited: A North Indian tertiary care centre study.

Purpose: To analyze and report ToRCH-serology screening profile (Toxoplasma gondii [TOX], rubella [RV], cytomegalovirus [CMV], and herpes simplex virus [HSV-I/II]) in pediatric cataract. Methods: In this prospective analytical study, 1,026 consecutive children were screened, of which 46 children with clinically diagnosed congenital (n = 26) and developmental cataract (n = 20) were included. Post-traumatic and familial cataracts were excluded. Sera of all children were tested both qualitatively and quantitatively for IgG/IgM-antibodies against ToRCH agents in a sequential manner. Results: Overall, IgM/IgG-seropositivity against ≥1 ToRCH agent was reported in 91.3% (42/46) children. IgM (±IgG) positivity against ≥1 ToRCH agent was reported in 26.08% (12/46) children (nine congenital and three developmental cataract; P = 0.18), which included 8.7% (4/46) children reported positive against ≥2 agents. Finally, 13% (6/46) children were reported to be sero-clinical-positive (three were infants and three were >1 year age, P = 0.55; five congenital and one developmental cataract, P = 0.21). Either alone or combined, RV attributed to the majority (50%; 6/12) of the IgM (±IgG) and sero-clinical-positive (50%; 3/6) children. None of the children were HSV-II IgM-positive. Laboratory-confirmed congenital rubella syndrome was reported in 4.3% (2/46) children. One sero-clinical-positive infant with rare coexisting bilateral persistent fetal vasculature was also reported. IgG-alone positivity was reported highest with CMV in 67.4% (31/46) children, whereas 43.4% (20/46) children were found nonimmune to RV. Conclusion: The current study emphasizes the need to interpret ToRCH-screening in pediatric cataract with caution. Interpretation should include both serial qualitative and quantitative assays in tandem with clinical correlation to minimize the diagnostic errors. Clinicians should remain vigilant regarding sero-clinical-positivity in older children too who might pose a threat to the spread of infection.

更新日期：2020-05-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南