Seven new cucurbitane-type triterpenoids, kuguaovins A-G (1-7), and five known ones were isolated from the rattans of wild Momordica charantia. Their structures were established by spectroscopic data analyses, including 1D and 2D NMR, IR, and MS techniques. The absolute configurations of the cucurbitanes were determined from NOESY data and partially by X-ray crystallographic analysis. In pharmacological studies, compounds 1-7 and 9-12 exhibited weak anti-inflammatory effects (IC50 = 15-35 μM), based on an anti-NO production assay.

中文翻译：

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苦瓜藤中的葫芦烷型三萜类化合物及其抗炎活性。

从野生苦瓜藤中分离出 7 种新的葫芦烷型三萜类化合物 kuguaovins AG (1-7) 和 5 种已知的三萜类化合物。它们的结构是通过光谱数据分析确定的，包括一维和二维核磁共振、红外和质谱技术。葫芦烷的绝对构型由 NOESY 数据和部分 X 射线晶体分析确定。在药理学研究中，基于抗 NO 产生测定，化合物 1-7 和 9-12 表现出较弱的抗炎作用 (IC50 = 15-35 μM)。