Cancer Photothermal Therapy with ICG-Conjugated Gold Nanoclusters.,Bioconjugate Chemistry

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Cancer Photothermal Therapy with ICG-Conjugated Gold Nanoclusters.
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-05-11 , DOI: 10.1021/acs.bioconjchem.0c00172
Xingya Jiang ₁ , Bujie Du ₁ , Yingyu Huang ₁ , Mengxiao Yu ₁ , Jie Zheng ₁

Affiliation

The coming era of precision nanomedicine demands engineered nanoparticles that can be readily translated into the clinic, like that of molecular agents, without being hindered by intrinsic size heterogeneity and long-term body retention. Herein we report that conjugation of indocyanine green (ICG), an FDA-approved near-infrared (NIR) dye, onto an atomically precise glutathione-coated Au25 (GS-Au25) nanocluster led to a molecular-like photothermal nanoparticle (ICG4-GS-Au25) with significantly enhanced ICG photostability and tumor targeting. Under weak NIR light irradiation conditions, free ICG failed to suppress tumor growth but the original tumors were completely eradicated with ICG4-GS-Au25. In the meantime, "off-target" ICG4-GS-Au25 was effectively cleared out from the body like small-molecule drugs after glutathione-mediated biotransformation in the liver. These findings highlight the merits of molecular-like nanomedicines, offering a new pathway to meet FDA's criteria for the clinical translation of nanomedicines.

中文翻译：

ICG 共轭金纳米团簇的癌症光热疗法。

即将到来的精密纳米医学时代需要工程化的纳米粒子，它可以像分子制剂一样轻松地转化为临床，而不会受到固有尺寸异质性和长期体内保留的阻碍。在此，我们报告了将吲哚菁绿 (ICG)（一种 FDA 批准的近红外 (NIR) 染料）缀合到原子级精确的谷胱甘肽涂层 Au25 (GS-Au25) 纳米簇上，产生了分子状光热纳米颗粒 (ICG4-GS) -Au25) 具有显着增强的 ICG 光稳定性和肿瘤靶向性。在弱近红外光照射条件下，游离ICG未能抑制肿瘤生长，但ICG4-GS-Au25可完全根除原始肿瘤。与此同时，“脱靶”的ICG4-GS-Au25在肝脏中通过谷胱甘肽介导的生物转化后，像小分子药物一样被有效地从体内清除。这些发现凸显了类分子纳米药物的优点，为满足 FDA 纳米药物临床转化标准提供了一条新途径。

更新日期：2020-04-30

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