Tandem Phospha‐Michael Addition/N‐Acylation/ Intramolecular Wittig Reaction of aza‐o‐Quinone Methides: Approaches to 2,3‐Disubstituted Indoles,Advanced Synthesis & Catalysis

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Tandem Phospha‐Michael Addition/N‐Acylation/ Intramolecular Wittig Reaction of aza‐o‐Quinone Methides: Approaches to 2,3‐Disubstituted Indoles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-04-29 , DOI: 10.1002/adsc.202000343
Ting‐Bi Hua _{1,

2} , Fei Chao ₁ , Long Wang ₁ , Chen‐Yang Yan ₁ , Cong Xiao ₃ , Qing‐Qing Yang _{1,

2} , Wen‐Jing Xiao ₄

Affiliation

A tandem phospha‐Michael addition/N‐acylation/intramolecular Wittig reaction of in situ formed aza‐o‐QMs is disclosed. This approach features high functional group tolerance and provides a convenient and practical access to biologically significant indole derivatives (37 examples, up to 91% yield) under mild reaction conditions.

中文翻译：

氮杂邻苯二甲酰甲烷的串联磷酸-迈克尔加成反应/ N-酰化反应/分子内维蒂希反应：制备2,3-二取代吲哚的方法

一种串联磷迈克尔加成/ Ñ酰化分子内形成的原位Wittig反应氮杂/ ö -QMs中公开。该方法具有高度的官能团耐受性，在温和的反应条件下，可方便实用地获得生物学上重要的吲哚衍生物（37个实例，产率高达91％）。

更新日期：2020-04-29

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