Allylic C(sp3)–H alkylation via synergistic organo- and photoredox catalyzed radical addition to imines,Chemical Science

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Allylic C(sp3)–H alkylation via synergistic organo- and photoredox catalyzed radical addition to imines
Chemical Science ( IF 7.6 ) Pub Date : 2020-04-30 , DOI: 10.1039/d0sc00819b
Jiaqi Jia _{1,

2,

3,

4,

5} , Rajesh Kancherla _{5,

6,

7,

8} , Magnus Rueping _{1,

2,

3,

4,

5} , Long Huang _{1,

2,

3,

4}

Affiliation

A new catalytic method for the direct alkylation of allylic C(sp³)–H bonds from unactivated alkenes via synergistic organo- and photoredox catalysis is described. The transformation achieves an efficient, redox-neutral synthesis of homoallylamines with broad functional group tolerance, under very mild reaction conditions. Mechanistic investigations indicate that the reaction proceeds through the N-centered radical intermediate which is generated by the allylic radical addition to the imine.

中文翻译：

烯丙基C（sp3）–H烷基化，通过有机和光氧化还原协同催化的亚胺基加成

描述了一种新的催化方法，用于通过协同的有机和光氧化还原催化作用，使未活化烯烃中的烯丙基C（sp ³）-H键直接烷基化。该转化在非常温和的反应条件下实现了具有宽泛的官能团耐受性的高烯丙基胺的高效，氧化还原中性合成。机理研究表明该反应通过以N为中心的自由基中间体进行，该中间体是通过将烯丙基自由基加成至亚胺而产生的。

更新日期：2020-04-30

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