Synthesis of Indolizine Derivatives Triggered by the Oxidative Addition of Aroyl Chloride to Pd(0) Complex.,The Journal of Organic Chemistry

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Synthesis of Indolizine Derivatives Triggered by the Oxidative Addition of Aroyl Chloride to Pd(0) Complex.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-05-07 , DOI: 10.1021/acs.joc.0c00161
Yahui Li ₁ , Wei Xiong ₁ , Zhifeng Zhang ₁ , Tongyu Xu ₁

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An efficient synthesis of indolizine derivatives from propargylic pyridines and aroyl chlorides was developed. The 5-endo-dig cyclization was initiated by the in situ formed acylpalladium species from the facile oxidative addition of aroyl chloride to Pd(0) complex. This transformation successfully occurred in the presence of an N-nucleophilic moiety and acid chlorides, a good electrophilic partner, affording highly functionalized indolizines in good-to-excellent yields.

中文翻译：

合成的Indolizine衍生物由Pro（0）络合物的氧化酰氯的氧化加成触发。

从炔丙基吡啶和芳酰氯有效地合成了吲哚嗪衍生物。5-endo-dig环化反应是由就地形成的酰基铝化合物从芳酰氯向Pd（0）络合物的容易氧化加成开始的。在N-亲核基团和酰基氯（一种良好的亲电伙伴）的存在下成功进行了该转化，从而以良好至优异的产率提供了高度官能化的吲哚嗪。

更新日期：2020-04-29

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