Bacterial Cellulose-Based Composite Scaffolds for Biomedical Applications: A Review,ACS Sustainable Chemistry & Engineering

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Bacterial Cellulose-Based Composite Scaffolds for Biomedical Applications: A Review
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-04-30 , DOI: 10.1021/acssuschemeng.0c00125
Wei Liu ₁ , Haishun Du ₂ , Miaomiao Zhang ₂ , Kun Liu ₁ , Huayu Liu ₁ , Hongxiang Xie ₁ , Xinyu Zhang ₂ , Chuanling Si _{1,

3}

Affiliation

Bacterial cellulose (BC), with non-toxicity, high purity, and biocompatibility, has been considered as a versatile candidate for various biomedical applications. Recently, the fabrication of BC-based composite scaffolds compounded with other ingredients such as nanoparticles and polymers has received extensive investigation, which enabled the development of numerous promising biomedical products. Additionally, BC-derived nanocrystals (BCNCs) and nanofibrils (BCNFs) have proven to be promising reinforcing agents in a variety of polymeric scaffolds for biomedical applications. In this review, we summarize recent preparation strategies for BC-based and BCNCs- and BCNFs-containing composite scaffolds and their advances in biomedical applications, including wound healing, tissue engineering, and drug delivery, as well as tumor cell culture and cancer treatment. Finally, we present challenges and future perspectives for BC-based composite scaffolds for biomedical applications.

中文翻译：

用于生物医学应用的细菌纤维素基复合支架：综述

细菌纤维素（BC）具有无毒，高纯度和生物相容性，已被认为是各种生物医学应用的多用途候选人。最近，与其他成分（例如纳米颗粒和聚合物）混合的基于BC的复合支架的制造已得到广泛的研究，这使得能够开发出许多有前途的生物医学产品。此外，已证明，BC衍生的纳米晶体（BCNC）和纳米原纤维（BCNF）在各种生物医学应用的聚合物支架中是有希望的增强剂。在这篇综述中，我们总结了基于BC，含BCNCs和BCNFs的复合支架的最新制备策略，以及它们在生物医学应用中的进展，包括伤口愈合，组织工程和药物输送，以及肿瘤细胞培养和癌症治疗。最后，我们提出了用于生物医学的基于BC的复合支架的挑战和未来展望。

更新日期：2020-04-30

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