Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K,Journal of Chemical & Engineering Data

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Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2020-04-29 , DOI: 10.1021/acs.jced.0c00097
Yanmin Shen ₁ , Wenju Liu ₁ , Chen Sun ₁ , Paifeng Shi ₁

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The solid–liquid phase equilibrium solubility of doxycycline hyclate (DH) in 10 pure organic solvents and cosolvent mixtures DMF (1) + ethanol (2), DMSO (1) + ethanol (2) and acetone (1) + ethanol (2) at a temperature range from 278.15 to 323.15 K was measured and discussed. The results indicated that the experimental mole fraction (x) of DH in 10 neat solvents followed this order: acrylic acid > acetic acid > 1-butanol > 1-pentanol > tetrahydrofuran > isobutyl alcohol > isopropyl alcohol> propanoic acid > acetone > acetonitrile, and temperature affected obviously the solubility especially in acetic acid. Moreover, the experimental mole fraction (x) of DH increased with mass concentration rising of DMF or DMSO in DMF (1) + ethanol (2) or DMSO (1) + ethanol (2), and decreased gradually with mass concentration rising of acetone in acetone (1) + ethanol (2). The experimental solubility in all solvents was correlated better by the modified Apelblat model according to lower values of RAD and RMSD.

中文翻译：

盐酸多西环素在278.15–323.15 K下的10种纯溶剂和混合溶剂中的溶解度测量和相关性

盐酸多西环素（DH）在10种纯有机溶剂和共溶剂混合物DMF（1）+乙醇（2），DMSO（1）+乙醇（2）和丙酮（1）+乙醇（2）中的固液相平衡溶解度在278.15至323.15 K的温度范围内进行了测量和讨论。结果表明，DH在10种纯溶剂中的实验摩尔分数（x）依次为：丙烯酸>乙酸> 1-丁醇> 1-戊醇>四氢呋喃>异丁醇>异丙醇>丙酸>丙酮>乙腈，温度对温度的影响明显，特别是在乙酸中的溶解度。此外，实验摩尔分数（x）的DH随DMF（1）+乙醇（2）或DMSO（1）+乙醇（2）中DMF或DMSO的质量浓度升高而增加，并随着丙酮（1）+乙醇（1）中的丙酮质量浓度升高而逐渐降低2）。根据RAD和RMSD的较低值，改进的Apelblat模型可以更好地关联在所有溶剂中的实验溶解度。

更新日期：2020-04-29

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