Extracellular Matrix in Vascular Disease, Part 2/4,Journal of the American College of Cardiology

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Extracellular Matrix in Vascular Disease, Part 2/4
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.jacc.2020.03.018
Javier Barallobre-Barreiro ₁ , Bart Loeys ₂ , Manuel Mayr ₃ , Marieke Rienks ₁ , Aline Verstraeten ₄ , Jason C Kovacic ₅

Affiliation

Medium-sized and large arteries consist of 3 layers: the tunica intima, tunica media, and tunica adventitia. The tunica media accounts for the bulk of the vessel wall and is the chief determinant of mechanical compliance. It is primarily composed of circumferentially arranged layers of vascular smooth muscle cells that are separated by concentrically arranged elastic lamellae; a form of extracellular matrix (ECM). The tunica media is separated from the tunica intima and tunica adventitia, the innermost and outermost layers, respectively, by the internal and external elastic laminae. This second part of a 4-part JACC Focus Seminar discusses the contributions of the ECM to vascular homeostasis and pathology. Advances in genetics and proteomics approaches have fostered significant progress in our understanding of vascular ECM. This review highlights the important role of the ECM in vascular disease and the prospect of translating these discoveries into clinical disease biomarkers and potential future therapies.

中文翻译：

血管疾病中的细胞外基质，第 2/4 部分

中型和大型动脉由 3 层组成：内膜、中膜和外膜。中膜占血管壁的大部分，是机械顺应性的主要决定因素。它主要由周向排列的血管平滑肌细胞层组成，由同心排列的弹性薄片隔开；细胞外基质 (ECM) 的一种形式。中膜与内膜和外膜，最内层和最外层分别通过内部和外部弹性层分开。由 4 部分组成的 JACC 焦点研讨会的第二部分讨论了 ECM 对血管稳态和病理学的贡献。遗传学和蛋白质组学方法的进步促进了我们对血管 ECM 理解的重大进展。

更新日期：2020-05-01

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