A new simple, technological, and environmentally friendly method for the catalyst-free synthesis in water of a promising antituberculosis drug, 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, was developed. The amount of the solvent in the reaction mixture has a decisive effect on the yield and purity of the target product.

中文翻译：

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三组分绿色合成 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a] 嘧啶，一种有前景的抗结核药物

一种新的简单、技术和环保的方法，用于在水中无催化剂合成有前景的抗结核药物 6-乙氧基羰基-5-甲基-7-(thien-2-yl)-4,7-dihydro[1, 2,4]三唑并[1,5-a]嘧啶被开发出来。反应混合物中溶剂的量对目标产物的产率和纯度具有决定性影响。