Abstract The water-dispersibility of hydrophobic polyphenols can be enhanced using nanotechnology-based approaches. Previous studies have shown that curcumin nanoparticles fabricated by a pH-shift method have a good water-dispersibility and a high loading capacity. Moreover, this method has considerable potential for large-scale commercial production of nutraceutical-loaded delivery systems for food applications. In this study, four kinds of amphiphilic biopolymers (sodium caseinate (SC), whey protein isolate (WPI), soy protein isolate (SPI), and gum Arabic (GA)) were used to coat curcumin nanoparticles (CNPs) produced by the pH-shift method. The encapsulation efficiency, loading capacity, particle dimensions, electrical potential, morphology, and stability of the CNPs were characterized. The four biopolymers could all stabilize aqueous dispersions of the CNPs and had a relatively high loading capacity. The maximum loading capacities of the SC, WPI, SPI, and GA-coated CNPs were 27%, 21%, 12%, and 9%, respectively. The resistance of the biopolymer-coated CNPs to changes in environmental conditions depended strongly on biopolymer type. GA coatings gave the best pH and salt stability, whereas SC and SPI gave the best thermal stability.

中文翻译：

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利用生物聚合物稳定通过 pH 转移法制备的姜黄素纳米颗粒：酪蛋白酸盐、乳清蛋白、大豆蛋白和阿拉伯树胶

摘要 使用基于纳米技术的方法可以增强疏水性多酚的水分散性。先前的研究表明，通过 pH 转移法制备的姜黄素纳米颗粒具有良好的水分散性和高负载能力。此外，这种方法在用于食品应用的营养食品递送系统的大规模商业生产方面具有相当大的潜力。在这项研究中，四种两亲性生物聚合物（酪蛋白酸钠 (SC)、乳清分离蛋白 (WPI)、大豆分离蛋白 (SPI) 和阿拉伯树胶 (GA)) 被用于包覆由 pH 值产生的姜黄素纳米颗粒 (CNPs)。 - 转移方法。表征了CNP的包封效率、负载能力、颗粒尺寸、电势、形态和稳定性。这四种生物聚合物都可以稳定 CNP 的水分散体，并具有相对较高的负载能力。SC、WPI、SPI 和 GA 涂层 CNP 的最大负载能力分别为 27%、21%、12% 和 9%。生物聚合物包覆的 CNP 对环境条件变化的抵抗力在很大程度上取决于生物聚合物的类型。GA 涂层具有最佳的 pH 值和盐稳定性，而 SC 和 SPI 具有最佳的热稳定性。