A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host-guest crosslinker.,Biomaterials Science

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A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host-guest crosslinker.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-04-23 , DOI: 10.1039/d0bm00290a
Yang Zhou ₁ , Yuanhao Zhang , Zhaobo Dai , Fang Jiang , Jia Tian , Weian Zhang

Affiliation

Supramolecular hydrogels based on host–guest interactions have drawn considerable attention due to their unique properties and promising applications. However, it is still a great challenge to construct supramolecular hydrogels that simultaneously achieve mechanical strength, processability, and biocompatibility. Herein, we present a rational design of a “supramolecular crosslinker” approach to fabricate a new host–guest hydrogel with super-stretchability, self-healing, and injectable properties and excellent biocompatibility. The star-shaped supramolecular crosslinker is formed by the host–guest interactions between octa-cyclodextrin polyhedral oligomeric silsesquioxane (OCDPOSS) and acrylamide-modified adamantane (Ad-AAm). Supramolecular hydrogels can be briefly prepared by UV-initiated copolymerization of acrylamide and supramolecular crosslinkers. Supramolecular hydrogels present impressive mechanical properties due to rigid POSS as the core of the supramolecular crosslinker. Moreover, multivalent host–guest interactions improve the ductility, rapid self-healing and injectable ability of these hydrogels. Simultaneously, these supramolecular hydrogels possess good biocompatibility and can be utilized as carriers for the sustained release of hydrophobic drugs. Thus, such supramolecular hydrogels will have potential applications for tissue engineering and drug delivery systems.

中文翻译：

由主体-客体交联剂构建的超可拉伸，自修复和可注射的超分子水凝胶。

基于宿主-客体相互作用的超分子水凝胶因其独特的性能和广阔的应用前景而备受关注。然而，构建同时实现机械强度，可加工性和生物相容性的超分子水凝胶仍然是巨大的挑战。本文中，我们提出了一种“超分子交联剂”方法的合理设计，以制造一种具有超强可拉伸性，自愈性，可注射性和出色的生物相容性的新型主客体水凝胶。星形超分子交联剂是由八环糊精多面体低聚倍半硅氧烷（OCDPOSS）和丙烯酰胺改性的金刚烷（Ad-AAm）之间的主体-客体相互作用形成的。超分子水凝胶可以通过丙烯酰胺和超分子交联剂的紫外线引发的共聚反应简单地制备。由于刚性POSS作为超分子交联剂的核心，超分子水凝胶具有令人印象深刻的机械性能。此外，多价宿主与客体的相互作用改善了这些水凝胶的延展性，快速的自我修复和可注射的能力。同时，这些超分子水凝胶具有良好的生物相容性，可以用作持续释放疏水性药物的载体。因此，这种超分子水凝胶将在组织工程和药物递送系统中具有潜在的应用。多价宿主与客体的相互作用改善了这些水凝胶的延展性，快速的自我修复和注射能力。同时，这些超分子水凝胶具有良好的生物相容性，可以用作持续释放疏水性药物的载体。因此，这种超分子水凝胶将在组织工程和药物递送系统中具有潜在的应用。多价宿主与客体的相互作用改善了这些水凝胶的延展性，快速的自我修复和注射能力。同时，这些超分子水凝胶具有良好的生物相容性，可以用作持续释放疏水性药物的载体。因此，这种超分子水凝胶将在组织工程和药物递送系统中具有潜在的应用。

更新日期：2020-04-23

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