Astragali Radix (Huangqi): A promising edible immunomodulatory herbal medicine.,Journal of Ethnopharmacology

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Astragali Radix (Huangqi): A promising edible immunomodulatory herbal medicine.
Journal of Ethnopharmacology ( IF 4.8 ) Pub Date : 2020-04-21 , DOI: 10.1016/j.jep.2020.112895
Zhejie Chen ₁ , Lijuan Liu ₂ , Caifang Gao ₁ , Weijie Chen ₁ , Chi Teng Vong ₁ , Peifen Yao ₁ , Yuhan Yang ₁ , Xiuzhu Li ₁ , Xudong Tang ₃ , Shengpeng Wang ₁ , Yitao Wang ₁

Affiliation

Ethnopharmacological relevance

Astragali Radix (AR, Huangqi in Chinese), the dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or A. membranaceus (Fisch.) Bge., possesses diverse therapeutic effects against fatigue, dyspepsia, diarrhea, heart diseases, hepatitis, and anemia. In recent years, increasing evidence has indicated the multiple immunomodulatory activities of AR in preclinical and clinical studies.

Aim of the review

This review attempts to elaborate the immunomodulatory effects of AR and its potential application in the treatment of immune related diseases.

Materials and methods

A comprehensive literature search AR was carried out using multiple internationally recognized databases (including Web of Science, Google Scholar, PubMed, ScienceDirect, Wiley, ACS, Springer, Taylor & Francis, and CNKI).

Results

The immunomodulatory effects of AR are closely attributed to its active constituents such as polysaccharides, saponins, and flavonoids. We also demonstrate that AR can be used as a potential therapeutic intervention for immune related diseases through regulating immune organs, mucosal immune, and immune system (innate immunity and acquired immunity).

Conclusion

AR promotes the development of immune organs, enhances mucosal immune function, increases the quantity and phagocytic capacity of innate immunity, promotes the maturation and differentiation of acquired immunity cells, and improves the expression of antibodies in acquired immunity. We believe that AR has a broad research space in the adjuvant treatment of immune related diseases, which could be a breakthrough point to improve the application value of AR.

中文翻译：

黄芪（黄芪）：一种有前途的食用免疫调节草药。

民族药理学意义

黄芪（AR，Huangqi），黄芪（Fisch。Bge）的干燥根。变种蒙古（Age。Mongholicus）（小）或膜（A. membranaceus（Fisch。））（B.）具有抗疲劳，消化不良，腹泻，心脏病，肝炎和贫血的多种治疗作用。近年来，越来越多的证据表明AR在临床前和临床研究中具有多种免疫调节活性。