Sulfachloropyridazine (SCP) was commonly used as a broad-spectrum sulfonamide antibiotic and hard to be removed through traditional sewage treatment process. In this study, we developed a simple and controllable strategy to realize in-situ construction of Co(OH)₂ nanoparticles decorated urchin-like WO₃ (Co(OH)₂/WO₃), which could efficiently remove SCP through peroxymonosulfate (PMS) activation. Some tiny nanoparticles of Co(OH)₂ decorated on the spines/nanorods or surfaces of urchin-like WO₃ by transmission electron microscopy (TEM) analysis. The obtained 10 wt% Co(OH)₂/WO₃ realized completely removal of SCP (degradation efficiency 100 %) with a high reaction rate constant (k₁) of 0.88 min^-1 within 3 min at optimal pH 7. That was because the urchin-like WO₃ with numerous adsorption functional groups on its surface (e.g., W=O and –OH bonds) could adsorb the Co²⁺ easily to form CoOH⁺, which was perceived the rate-limiting step for PMS activation and generating radicals. Radical quenching experiments indicated that SO₄^{• –} played a more significant role than HO^• radicals. Density functional theory (DFT) calculation revealed that the atoms of SCP with high Fukui index (f ^–) were active sites, which preferred to be attacked by the electrophilic SO₄^{• –} and HO^• radicals. The toxicity of the intermediates by SCP degradation was evaluated by quantitative structure-activity relationship (QSAR) prediction through Toxicity Estimation Software Tool (T.E.S.T.). The possible degradation pathway and catalytic mechanism for SCP removal were proposed. Considering the good catalytic properties of Co(OH)₂/WO₃-PMS, the material will show great application potential in the removal of emerging contaminants in water.

磺胺氯哒嗪（SCP）通常用作广谱磺酰胺类抗生素，很难通过传统的污水处理工艺去除。在这项研究中，我们开发了一种简单且可控的策略，以实现原位构建装饰有顽童状WO ₃（Co（OH）₂ / WO ₃）的Co（OH）₂纳米颗粒，该纳米颗粒可通过过一硫酸盐（PMS）有效去除SCP ）激活。通过透射电子显微镜（TEM）分析，在棘突/纳米节或类顽童WO ₃的表面上装饰了一些微小的Co（OH）₂纳米颗粒。所获得的10重量％的Co（OH）₂ / WO ₃实现了在最佳pH值为3的情况下在3分钟内以0.88 min ^-1的高反应速率常数（k ₁）完全清除SCP（降解效率100％）的原因。这是因为在其上具有许多吸附官能团的类似海胆的WO ₃表面（例如W = O和–OH键）可以轻松吸附Co ²⁺形成CoOH ⁺，这被认为是PMS活化和产生自由基的限速步骤。自由基猝灭实验表明，SO ₄ ^•-的作用比HO ^•自由基更重要。密度泛函理论（DFT）计算表明，具有高福井指数的SCP原子（f ^–）是活性位点，更倾向于被亲电子的SO ₄ ^•–和HO ^•自由基攻击。通过毒性估算软件工具（TEST）通过定量构效关系（QSAR）预测评估了SCP降解中间体的毒性。提出了去除SCP的可能的降解途径和催化机制。考虑到Co（OH）₂ / WO ₃ -PMS的良好催化性能，该材料在去除水中新兴污染物方面将显示出巨大的应用潜力。