CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes.,Nature Communications

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CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes.
Nature Communications ( IF 14.7 ) Pub Date : 2020-04-22 , DOI: 10.1038/s41467-020-15857-x
Chikako Shimokawa _{1,

2,

3} , Tamotsu Kato _{3,

4} , Tadashi Takeuchi _{3,

5} , Noriyasu Ohshima ₆ , Takao Furuki ₇ , Yoshiaki Ohtsu ₈ , Kazutomo Suzue ₂ , Takashi Imai ₂ , Seiji Obi ₂ , Alex Olia _{1,

2} , Takashi Izumi ₆ , Minoru Sakurai ₇ , Hirokazu Arakawa ₈ , Hiroshi Ohno _{3,

4,

9} , Hajime Hisaeda _{1,

2}

Affiliation

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and immunosuppressive infections and suppress disease in rodent models of T1D. However, the underlying regulatory mechanisms for this protection are unclear. Here, we report that CD8+ regulatory T (Treg) cells prevent the onset of streptozotocin -induced diabetes by a rodent intestinal nematode. Trehalose derived from nematodes affects the intestinal microbiota and increases the abundance of Ruminococcus spp., resulting in the induction of CD8+ Treg cells. Furthermore, trehalose has therapeutic effects on both streptozotocin-induced diabetes and in the NOD mouse model of T1D. In addition, compared with healthy volunteers, patients with T1D have fewer CD8+ Treg cells, and the abundance of intestinal Ruminococcus positively correlates with the number of CD8+ Treg cells in humans.

中文翻译：

CD8 +调节性T细胞对于预防自身免疫介导的糖尿病至关重要。

1型糖尿病（T1D）是一种自身免疫性疾病，其中会破坏产生胰岛素的胰岛β细胞。在T1D啮齿动物模型中，肠道蠕虫可引起无症状的慢性和免疫抑制感染并抑制疾病。但是，这种保护的基本调控机制尚不清楚。在这里，我们报道CD8 +调节性T（Treg）细胞可防止啮齿动物肠道线虫感染链脲佐菌素诱发的糖尿病。来源于线虫的海藻糖会影响肠道菌群，并增加Ruminococcus spp。的丰度，从而诱导CD8 + Treg细胞。此外，海藻糖对链脲佐菌素诱发的糖尿病和T1D的NOD小鼠模型均具有治疗作用。此外，与健康志愿者相比，T1D患者的CD8 + Treg细胞更少，

更新日期：2020-04-24

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