Scalable Synthesis of S-Fluoromethyl Benzenesulfonothioate,Organic Process Research & Development

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Scalable Synthesis of S-Fluoromethyl Benzenesulfonothioate
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-04-21 , DOI: 10.1021/acs.oprd.0c00101
Qunchao Zhao ₁ , Ruichao Yao ₂ , Wenbo Chen ₂ , Long Lu ₁ , Qilong Shen ₁

Affiliation

A general and practical method for the preparation of S-fluoromethyl benzenesulfonothioate on a 500 g scale in two steps from readily available CH₂FCl, sulfur, and sodium benzenesulfinate is reported. The reaction was found to be rather sensitive to water and temperature. Furthermore, the main side product of the reaction was identified to be S-phenyl benzenesulfonothioate.

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