当前位置: X-MOL 学术Org. Process Res. Dev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Scalable Synthesis of S-Fluoromethyl Benzenesulfonothioate
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-04-21 , DOI: 10.1021/acs.oprd.0c00101
Qunchao Zhao 1 , Ruichao Yao 2 , Wenbo Chen 2 , Long Lu 1 , Qilong Shen 1
Affiliation  

A general and practical method for the preparation of S-fluoromethyl benzenesulfonothioate on a 500 g scale in two steps from readily available CH2FCl, sulfur, and sodium benzenesulfinate is reported. The reaction was found to be rather sensitive to water and temperature. Furthermore, the main side product of the reaction was identified to be S-phenyl benzenesulfonothioate.

中文翻译:

S-氟甲基苯硫基磺酸酯的可扩展合成

报道了一种通用且实用的方法,该方法从容易获得的CH 2 FCl,硫和苯亚磺酸钠分两步制备500 g规模的S-氟甲基苯磺酸硫酯。发现该反应对水和温度相当敏感。此外,该反应的主要副产物被鉴定为S-苯基苯磺酸硫代盐。
更新日期:2020-06-19
down
wechat
bug