Plant activators are chemicals that induce plant defense responses to various pathogens. Here, we reported a new potential plant activator, 6-(methoxymethyl)-2-[5-(trifluoromethyl)-2-pyridyl] pyrimidin-4-ol, named PPA2 (pyrimidin-type plant activator 2). Unlike the traditional commercial plant activator benzothiadiazole S-methyl ester (BTH), PPA2 was fully soluble in water, and it did not inhibit plant growth or root system development in rice (Oryza sativa). PPA2 pretreatment significantly increased plant resistance against bacterial infection in both Arabidopsis and rice, in conjunction with increases in the level of jasmonoyl-isoleucine and 12-oxo-phytodienoic acid. In addition, metabolite profiling indicated that BTH significantly reduced the abundance of various primary metabolites in rice seedlings, including most amino acids, sugars, and organic acids; by contrast, PPA2 promoted their synthesis. Our results thus indicate that PPA2 enhances plant defenses against bacterial infection through the jasmonic acid pathway, and that as a water-soluble compound that can promote the synthesis of primary metabolites it has broad potential applications in agriculture.

中文翻译：

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嘧啶样植物激活剂刺激植物抗病性并促进主要代谢产物的合成。

植物激活剂是诱导植物对各种病原体防御反应的化学物质。在这里，我们报道了一种新的潜在的植物活化剂，6-（甲氧基甲基）-2- [5-（三氟甲基）-2-吡啶基]嘧啶-4-醇，命名为PPA2（嘧啶类植物活化剂2）。与传统的商用植物活化剂苯并噻二唑S-甲基酯（BTH）不同，PPA2完全溶于水，并且不抑制水稻（Oryza sativa）中的植物生长或根系发育。PPA2预处理显着提高了植物对拟南芥和水稻的细菌感染抵抗力，同时茉莉单基-异亮氨酸和12-氧代-植物二烯酸的含量也增加了。此外，代谢物分析表明，BTH显着降低了水稻幼苗中各种主要代谢物的丰度，包括大多数氨基酸，糖，和有机酸；相比之下，PPA2促进了它们的合成。因此，我们的结果表明，PPA2通过茉莉酸途径增强了植物抵抗细菌感染的防御能力，并且作为一种可促进主要代谢产物合成的水溶性化合物，它在农业中具有广泛的潜在应用。