FePt Nanoparticles Embedded in Metal–Organic Framework Nanoparticles for Tumor Imaging and Eradication,ACS Applied Nano Materials

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FePt Nanoparticles Embedded in Metal–Organic Framework Nanoparticles for Tumor Imaging and Eradication
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2020-04-20 , DOI: 10.1021/acsanm.0c00581
Yanfei Meng _{1,

2} , Dongsheng Zhang ₁ , Xue Chen ₁ , Zhichao Dai _{1,

2} , Xiuxiu Yao _{1,

3} , Ping Cui _{1,

2} , Dexin Yu ₄ , Gaorui Zhang ₄ , Xiuwen Zheng _{1,

2}

Affiliation

In the tumor microenvironment (TME), an efficient Fenton reaction agent could have attractive tumor therapeutic efficacy, which is primarily based on delivering drugs to the tumor accurately and depressing undesirable side effects. Here, a metal–organic framework (MOF), with good biocompatibility and high loading capacity, with encapsulated FePt NPs (FePt-MOF NCs) and face-centered cubic (fcc)-FePt was successfully designed to eradicate cancer cells. The as-prepared multifunctional FePt-MOF NCs serve as a nanotheranostic agent for magnetic resonance/computed tomography (MR/CT) dual-modal imaging based on superparamagnetism and cancer therapy due to the well-known Fenton reactions. The drug nanodelivery system based on MOFs was able to safely deliver on the basis of intravenous administration. Because of its high sensitivity to acidic environments, the FePt-MOF would collapse and further release Fe and Pt ions, which would effectively trigger the Fenton reaction to produce plentiful toxic hydroxyl radicals in the acidic tumor microenvironment. On the one hand, the radicals could result in apoptotic cell death, whereas, on the other hand, they also lure the cumulation of lipid peroxides, causing tumor cell ferroptosis. These results indicated the great potential of the FePt-MOF NCs as a multifunction platform for tumor therapeutic and image applications.

中文翻译：

FePt纳米颗粒嵌入金属-有机骨架纳米颗粒中，用于肿瘤成像和根除

在肿瘤微环境（TME）中，有效的Fenton反应剂可能具有诱人的肿瘤治疗功效，这主要基于准确地将药物递送至肿瘤并抑制不良副作用。在这里，成功设计了具有良好生物相容性和高负载能力的金属-有机骨架（MOF），并封装了FePt NP（FePt-MOF NCs）和面心立方（fcc）-FePt。所制备的多功能FePt-MOF NC由于众所周知的Fenton反应，可作为基于超顺磁性和癌症治疗的磁共振/计算机断层扫描（MR / CT）双峰成像的纳米热能剂。基于MOFs的药物纳米递送系统能够在静脉内给药的基础上安全地递送。由于它对酸性环境高度敏感，FePt-MOF会坍塌并进一步释放Fe和Pt离子，这将有效触发Fenton反应，从而在酸性肿瘤微环境中产生大量有毒的羟基自由基。一方面，这些自由基可能导致凋亡的细胞死亡，而另一方面，它们也诱使脂质过氧化物的积累，从而导致肿瘤细胞的肥大。这些结果表明FePt-MOF NCs作为用于肿瘤治疗和图像应用的多功能平台具有巨大的潜力。引起肿瘤细胞肥大。这些结果表明FePt-MOF NCs作为用于肿瘤治疗和图像应用的多功能平台具有巨大的潜力。引起肿瘤细胞肥大。这些结果表明FePt-MOF NCs作为用于肿瘤治疗和图像应用的多功能平台具有巨大的潜力。

更新日期：2020-04-20

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