School of Chemistry; Analytical and Biological Chemistry Research Facility; University College Cork; Kane Building T12 K8AF Cork Ireland
School of Pharmacy; University College Cork; Cork Ireland
SSPC (Synthesis and Solid State Pharmaceutical Centre); Cork Ireland
Department für Chemie; Universität zu Köln; Greinstraße 4 50939 Köln Germany
已经开发了一种基于1 H- 15 N，1 H- 13 C HMBC和13 C { 1 H} NMR光谱的分析方法，可以明确诊断芳族N-杂环和N的N-或O-烷基化的发生氧化物。一个系统的大高磁场位移在矿井15 ÑNMR化学位移被示出为芳族的N-杂环的N-烷基化的特性（Δ（δ Ñ）≈-100 ppm）表示。在δ甲小得多系统性变化Ñ指示Ñ氧化物O-烷基化（约-40 ppm）表示。
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Identification of N‐ or O‐Alkylation of Aromatic Nitrogen Heterocycles and N‐Oxides Using 1H–15N HMBC NMR Spectroscopy
An analytical method based on 1H–15N, 1H–13C HMBC and 13C{1H} NMR spectroscopy has been developed that allows unambiguous diagnosis of the occurrence of N‐ or O‐alkylation of aromatic N‐heterocycles and N ‐oxides. A systematic large upfield shift inthe 15N NMR chemical shift is shown to be characteristic of N‐alkylation of aromatic N‐heterocycles (Δ(δN) ≈ –100 ppm). A much smaller systematic change in δN is indicative of N ‐oxide O‐alkylation (ca. –40 ppm).
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