A practical and concise synthesis of 4-methylumbelliferyl α- l -idopyranosiduronic acid, a fluorogenic enzyme substrate diagnostic for α- l -iduronidase, was accomplished. It features successive radical bromination and radical reduction of easily accessible methyl 4-methyl­umbelliferyl-2,3,4-tri-O-acetyl-β- d -glucouronate in four steps with 28% overall yield.

中文翻译：

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荧光酶底物 4-Methylumbelliferyl α-l-Idopyranosiduronic Acid 的实用合成

4-methylumbelliferyl α-l-idopyranosiduronic acid 的实用和简洁的合成已经完成，它是一种用于诊断 α-l-艾杜糖苷酸酶的荧光酶底物。它的特点是易于获得的 4-甲基伞形酮基-2,3,4-三-O-乙酰基-β-d-葡萄糖醛酸甲酯的连续自由基溴化和自由基还原分四步进行，总产率为 28%。