DNA-Polymer Nanostructures by RAFT Polymerization and Polymerization-Induced Self-Assembly.,Angewandte Chemie International Edition

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DNA-Polymer Nanostructures by RAFT Polymerization and Polymerization-Induced Self-Assembly.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-04-17 , DOI: 10.1002/anie.201916177
Thorsten Lückerath ₁ , Kaloian Koynov ₁ , Sebastian Loescher _{2,

3} , Colette J Whitfield ₁ , Lutz Nuhn ₁ , Andreas Walther _{2,

3} , Christopher Barner-Kowollik _{4,

5} , David Y W Ng ₁ , Tanja Weil ₁

Affiliation

Nanostructures derived from amphiphilic DNA–polymer conjugates have emerged prominently due to their rich self‐assembly behavior; however, their synthesis is traditionally challenging. Here, we report a novel platform technology towards DNA–polymer nanostructures of various shapes by leveraging polymerization‐induced self‐assembly (PISA) for polymerization from single‐stranded DNA (ssDNA). A “grafting from” protocol for thermal RAFT polymerization from ssDNA under ambient conditions was developed and utilized for the synthesis of functional DNA–polymer conjugates and DNA–diblock conjugates derived from acrylates and acrylamides. Using this method, PISA was applied to manufacture isotropic and anisotropic DNA–polymer nanostructures by varying the chain length of the polymer block. The resulting nanostructures were further functionalized by hybridization with a dye‐labelled complementary ssDNA, thus establishing PISA as a powerful route towards intrinsically functional DNA–polymer nanostructures.

中文翻译：

通过 RAFT 聚合和聚合诱导的自组装形成 DNA 聚合物纳米结构。

源自两亲性 DNA-聚合物缀合物的纳米结构因其丰富的自组装行为而引人注目；然而，它们的合成传统上具有挑战性。在这里，我们报告了一种针对各种形状的 DNA 聚合物纳米结构的新型平台技术，利用聚合诱导自组装 (PISA) 进行单链 DNA (ssDNA) 的聚合。开发了一种在环境条件下从 ssDNA 进行热 RAFT 聚合的“接枝”方案，并用于合成源自丙烯酸酯和丙烯酰胺的功能性 DNA-聚合物缀合物和 DNA-二嵌段缀合物。使用这种方法，PISA 通过改变聚合物嵌段的链长来制造各向同性和各向异性 DNA 聚合物纳米结构。由此产生的纳米结构通过与染料标记的互补 ssDNA 杂交进一步功能化，从而将 PISA 确立为实现内在功能性 DNA-聚合物纳米结构的强大途径。

更新日期：2020-04-17

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