A novel two-step synthesis of gem-difluoroallyl MIDA boronates, which are air- and moisture-stable fluorine-containing building blocks for potential applications in iterative cross-couplings, was developed. The first step involves cobalt- or copper-catalyzed defluoroborylation of α-trifluoromethyl alkenes with B₂pin₂ in the absence of ligand. Next, without further purification, the resulting gem-difluroallylboronic acid pinacol ester was converted to gem-difluoroallyl MIDA boronates by heating in the presence of MIDA.

中文翻译：

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钴或铜催化的α-三氟甲基烯烃合成宝石-二氟烯丙基MIDA硼酸盐

开发了新颖的两步合成宝石-二氟烯丙基MIDA硼酸盐，它是空气和水分稳定的含氟结构单元，可在迭代交叉偶联中潜在应用。第一步涉及在不存在配体的情况下用B ₂ pin ₂进行钴或铜催化的α-三氟甲基烯烃的脱氟硼化反应。接下来，无需进一步纯化，通过在MIDA的存在下加热，将所得的宝石-二氟烯丙二酸频哪醇酯转化为宝石-二氟烯丙基MIDA硼酸酯。