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Bioactive seco-Sativene Sesquiterpenoids from an Artemisia desertorum Endophytic Fungus, Cochliobolus sativus.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-04-17 , DOI: 10.1021/acs.jnatprod.9b01148
Yuan-Yuan Li 1 , Xiang-Mei Tan 1 , Yan-Duo Wang 1 , Jian Yang 2 , Yong-Gang Zhang 3 , Bing-Da Sun 4 , Ting Gong 5 , Lan-Ping Guo 2, 6 , Gang Ding 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-04-17 , DOI: 10.1021/acs.jnatprod.9b01148
Yuan-Yuan Li 1 , Xiang-Mei Tan 1 , Yan-Duo Wang 1 , Jian Yang 2 , Yong-Gang Zhang 3 , Bing-Da Sun 4 , Ting Gong 5 , Lan-Ping Guo 2, 6 , Gang Ding 1
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A series of seco-sativene sesquiterpenoids (1-11) including two new natural products (2 and 3), four new analogues (4-7), and six known analogues, helminthosporic acid (1), drechslerine A (8), drechslerine B (9), helminthosporol (10), helminthosporal acid (11), and isosativenediol (12), were purified from the endophytic fungus Cochliobolus sativus isolated from a desert plant, Artemisia desertorum. The stereochemistry of helminthosporic acid (1) was established for the first time by X-ray diffraction, and the structures including relative and absolute configurations of these new compounds were determined by NMR and CD spectra together with biosynthetic considerations. Compounds 5-7 are the first seco-sativene sesquiterpenoids possessing a glucose group on C-15, C-15, and C-14, respectively. Compounds 1, 7, 9, and 11 displayed strong phytotoxic effects on corn leaves by producing visible lesions, and helminthosporic acid (1) was shown to promote division of leaves and roots of Arabidopsis thaliana with a dose-dependent relationship.
中文翻译:
来自沙蒿蒿内生真菌Cochliobolus sativus的生物活性Seco-Sativene倍半萜类化合物。
一系列山核桃-倍半萜类化合物(1-11),包括两种新的天然产物(2和3),四种新的类似物(4-7)和六种已知的类似物,蠕虫孢子酸(1),屈曲菌素A(8),屈曲菌素B(9),杀虫酚(10),杀虫孢子酸(11)和异黄二醇(12)是从从沙漠植物蒿蒿中分离的内生真菌Cochliobolus sativus纯化的。首次通过X射线衍射建立了蠕虫孢子酸(1)的立体化学,并通过NMR和CD光谱以及生物合成考虑,确定了这些新化合物的相对和绝对构型的结构。化合物5-7是分别在C-15,C-15和C-14上具有葡萄糖基团的第一种癸二酸倍半萜。化合物1、7、9
更新日期:2020-04-17
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
来自沙蒿蒿内生真菌Cochliobolus sativus的生物活性Seco-Sativene倍半萜类化合物。
一系列山核桃-倍半萜类化合物(1-11),包括两种新的天然产物(2和3),四种新的类似物(4-7)和六种已知的类似物,蠕虫孢子酸(1),屈曲菌素A(8),屈曲菌素B(9),杀虫酚(10),杀虫孢子酸(11)和异黄二醇(12)是从从沙漠植物蒿蒿中分离的内生真菌Cochliobolus sativus纯化的。首次通过X射线衍射建立了蠕虫孢子酸(1)的立体化学,并通过NMR和CD光谱以及生物合成考虑,确定了这些新化合物的相对和绝对构型的结构。化合物5-7是分别在C-15,C-15和C-14上具有葡萄糖基团的第一种癸二酸倍半萜。化合物1、7、9