Synthesis of a Novel 1,4-Dicarbonyl Scaffold – Ethyl 3-Formyl-4,5-dihydrofuran-2-carboxylate – and Its Application to the Synthesis of Pyridazines,Synthesis

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Synthesis of a Novel 1,4-Dicarbonyl Scaffold – Ethyl 3-Formyl-4,5-dihydrofuran-2-carboxylate – and Its Application to the Synthesis of Pyridazines
Synthesis ( IF 2.2 ) Pub Date : 2020-04-14 , DOI: 10.1055/s-0039-1690886
Nilo Zanatta ₁ , Mário A. Marangoni , Paulo A. Moraes , Adriano F. Camargo , Helio G. Bonacorso , Marcos A. P. Martins

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The 1,4-dicarbonyl scaffold ethyl 3-formyl-4,5-dihydrofuran-2-carboxylate was obtained through the rearrangement of the parent ethyl 2-(4,5-dihydrofuran-3-yl)-2-oxoacetate and applied to the synthesis of a series of 7-alkoxy-2,3-dihydrofuro[2,3-d]pyridazines. Twelve pyridazines were obtained in yields of up to 70%.

中文翻译：

新型1,4-二羰基支架-3-甲酰基-4,5-二氢呋喃-2-羧酸乙酯的合成及其在哒嗪合成中的应用

通过对母体2-（4,5-二氢呋喃-3-基）-2-氧乙酸乙酯进行重排，获得了1,4-二羰基支架3-甲酰基-4,5-二氢呋喃-2-羧酸乙酯。一系列7-烷氧基-2,3-二氢呋喃[2,3- d ]哒嗪的合成。获得了十二种哒嗪，产率高达70％。

更新日期：2020-04-14

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