Advances in Uniform Polymer Microspheres and Microcapsules: Preparation and Biomedical Applications,Chinese Journal of Chemistry

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Advances in Uniform Polymer Microspheres and Microcapsules: Preparation and Biomedical Applications
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-04-14 , DOI: 10.1002/cjoc.202000135
Guanghui Ma _{1,

2} , Hua Yue ₁

Affiliation

Microspheres and microcapsules have been widely used in biomedical field, such as delivery systems for drugs, vaccines. Uniform particle is required for precise drug delivery and disease treatment, since the particle diameter is a key factor which controls the pharmacokinetics and efficacy of loaded drug. However, there is no universal method to prepare uniform particles either from monomer or preformed polymer raw materials. We have developed two membrane emulsification techniques (MET) to prepare uniform particles with controllable size. In this review, we introduce two MET processes and their mechanisms, and how to develop MET to different emulsion systems to obtain various uniform microspheres and microcapsules with interesting morphologies. Then, the advantages of uniform particles on biomedical application results are focused. Finally, particle design and applications as “Chassis” to form synthetic vaccine are described.

中文翻译：

均匀聚合物微球和微胶囊的进展：制备和生物医学应用

微球和微胶囊已广泛用于生物医学领域，例如药物，疫苗的递送系统。精确的药物输送和疾病治疗需要均匀的颗粒，因为粒径是控制负载药物的药代动力学和功效的关键因素。然而，目前尚无从单体或预制的聚合物原料制备均匀颗粒的通用方法。我们已经开发了两种膜乳化技术（MET），以制备尺寸可控的均匀颗粒。在这篇综述中，我们介绍了两种MET工艺及其机理，以及如何将MET开发到不同的乳液体系中，以获得各种具有有趣形态的均匀微球和微胶囊。然后，集中了均匀颗粒在生物医学应用结果上的优势。最后，

更新日期：2020-04-14

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