A Photoinduced Nonadiabatic Decay-Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy.,Angewandte Chemie International Edition

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A Photoinduced Nonadiabatic Decay-Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-04-13 , DOI: 10.1002/anie.202002516
Jen-Shyang Ni _{1,

2} , Xun Zhang ₁ , Guang Yang ₁ , Tianyi Kang ₁ , Xiangwei Lin ₃ , Menglei Zha ₁ , Yaxi Li ₁ , Lidai Wang ₃ , Kai Li ₁

Affiliation

It remains highly challenging to identify small molecule‐based photothermal agents with a high photothermal conversion efficiency (PTCE). Herein, we adopt a double bond‐based molecular motor concept to develop a new class of small photothermal agents to break the current design bottleneck. As the double‐bond is twisted by strong twisted intramolecular charge transfer (TICT) upon irradiation, the excited agents can deactivate non‐radiatively through the conical intersection (CI) of internal conversion, which is called photoinduced nonadiabatic decay. Such agents possess a high PTCE of 90.0 %, facilitating low‐temperature photothermal therapy in the presence of a heat shock protein 70 inhibitor. In addition, the behavior and mechanism of NIR laser‐triggered molecular motions for generating heat through the CI pathway have been further understood through theoretical and experimental evidence, providing a design principle for highly efficient photothermal and photoacoustic agents.

中文翻译：

光诱导的非绝热衰变引导分子马达触发有效的光热转换，用于癌症治疗。

识别具有高光热转换效率（PTCE）的基于小分子的光热剂仍然面临着巨大的挑战。本文中，我们采用基于双键的分子马达概念来开发新型的小型光热剂，以打破当前的设计瓶颈。由于双键在辐照时受到强烈扭曲的分子内电荷转移（TICT）的扭曲，因此激发剂可以通过内部转换的圆锥交点（CI）进行非辐射灭活，这称为光诱导的非绝热衰变。此类药物具有90.0％的高PTCE，在存在热激蛋白70抑制剂的情况下有助于进行低温光热疗法。此外，

更新日期：2020-04-13

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