Interplay between midbrain and dorsal anterior cingulate regions arbitrates lingering reward effects on memory encoding.,Nature Communications

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Interplay between midbrain and dorsal anterior cingulate regions arbitrates lingering reward effects on memory encoding.
Nature Communications ( IF 14.7 ) Pub Date : 2020-04-14 , DOI: 10.1038/s41467-020-15542-z
Kristoffer Carl Aberg ₁ , Emily Elizabeth Kramer _{2,

3} , Sophie Schwartz _{4,

5,

6}

Affiliation

Rewarding events enhance memory encoding via dopaminergic influences on hippocampal plasticity. Phasic dopamine release depends on immediate reward magnitude, but presumably also on tonic dopamine levels, which may vary as a function of the average accumulation of reward over time. Using model-based fMRI in combination with a novel associative memory task, we show that immediate reward magnitude exerts a monotonically increasing influence on the nucleus accumbens, ventral tegmental area (VTA), and hippocampal activity during encoding, and enhances memory. By contrast, average reward levels modulate feedback-related responses in the VTA and hippocampus in a non-linear (inverted U-shape) fashion, with similar effects on memory performance. Additionally, the dorsal anterior cingulate cortex (dACC) monotonically tracks average reward levels, while VTA-dACC functional connectivity is non-linearly modulated (inverted U-shape) by average reward. We propose that the dACC computes the net behavioral impact of average reward and relays this information to memory circuitry via the VTA.

中文翻译：

中脑和背前扣带回区域之间的相互作用决定了记忆编码上挥之不去的奖励效应。

奖励事件通过对海马可塑性的多巴胺能影响来增强记忆编码。阶段性多巴胺的释放取决于立即的奖励幅度，但大概也取决于补品的多巴胺水平，其随时间的推移随着奖励的平均积累而变化。使用基于模型的功能磁共振成像结合新型联想记忆任务，我们显示即时奖励幅度在编码过程中对伏隔核，腹侧被盖区（VTA）和海马活动施加单调增加的影响，并增强记忆。相比之下，平均奖励水平以非线性（倒U形）方式调节VTA和海马中与反馈相关的响应，对记忆性能的影响类似。此外，背扣带前皮质（dACC）单调跟踪平均奖励水平，而VTA-dACC的功能连通性是通过平均奖励进行非线性调制（倒U形）的。我们建议dACC计算平均奖励的净行为影响，并将此信息通过VTA中继到存储电路。

更新日期：2020-04-24

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