Reductive Coupling of Carbon Dioxide and an Aldehyde Mediated by a Copper(I) Complex toward the Synthesis of α-Hydroxycarboxylic Acids.,Organic Letters

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Reductive Coupling of Carbon Dioxide and an Aldehyde Mediated by a Copper(I) Complex toward the Synthesis of α-Hydroxycarboxylic Acids.
Organic Letters ( IF 4.9 ) Pub Date : 2020-04-13 , DOI: 10.1021/acs.orglett.0c00995
Koichiro Masada ₁ , Shuhei Kusumoto ₁ , Kyoko Nozaki ₁

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Copper-mediated reductive coupling between CO₂ and an aldehyde to form α-hydroxycarboxylic acid was achieved using silylborane as a reductant. CO₂ cleanly inserted into a copper–carbon bond that was formed by the reaction between a silylcopper–NHC complex and an aldehyde. A series of reactions that regenerate the silylcopper complex were developed for the synthesis of an α-hydroxycarboxylic acid. After repeating each step iteratively for two cycles, 0.62 equiv of α-hydroxycarboxylic acid based on the copper complex was obtained.

中文翻译：

二氧化碳与铜（I）配合物介导的醛的还原偶联对α-羟基羧酸的合成。

使用甲硅烷基硼烷作为还原剂实现了CO ₂与醛之间的铜介导的还原偶联，从而形成α-羟基羧酸。CO ₂干净地插入由甲硅烷基铜-NHC络合物与醛之间的反应形成的铜-碳键中。开发了一系列再生甲硅烷基铜配合物的反应，用于合成α-羟基羧酸。在将每个步骤重复重复两个循环之后，获得基于铜络合物的0.62当量的α-羟基羧酸。

更新日期：2020-04-13

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