通过体外分析和计算研究评估了苯并三唑紫外线稳定剂的雌激素活性。,Science of the Total Environment

当前位置： X-MOL 学术 › Sci. Total Environ. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

通过体外分析和计算研究评估了苯并三唑紫外线稳定剂的雌激素活性。
Science of the Total Environment ( IF 8.2 ) Pub Date : 2020-04-13 , DOI: 10.1016/j.scitotenv.2020.138549
Hongru Feng ₁ , Huiming Cao ₂ , Juan Li ₃ , Haiyan Zhang ₄ , Qiao Xue ₃ , Xian Liu ₃ , Aiqian Zhang ₅ , Jianjie Fu ₃

Affiliation

苯并三唑紫外线稳定剂（BUVs）用于多种产品中，以防止泛黄和降解。然而，仍然缺乏关于BUV的雌激素活性的知识。在本研究中，采用了结合体外测定和计算研究的策略来评估BUV的雌激素活性。2-（2-羟基-5-甲基苯基）苯并三唑（UV-P），2-（5-叔丁基-2-羟基苯基）苯并三唑（UV-PS）和2-（3-烯丙基-2-羟基- 5-甲基苯基）-2H-苯并三唑（UV-9）诱导部分雌激素活性，而2-（2-羟基-5-叔辛基-苯基）苯并三唑（UV-329），2-（3-s-丁基-5 -叔丁基-2-羟基苯基）苯并三唑（UV-350）和3-（2H-苯并三唑基）-5-（1,1-二甲基乙基）-4-羟基苯丙酸辛酯（UV- 384）在MVLN分析中未显示雌激素活性。体外测定的结果与计算研究的结果一致。此外，ICI 182,780在不存在和存在E2的情况下均抑制了BUV的雌激素活性，表明BUV的雌激素反应元件（ERE）转录活性是通过雌激素受体（ER）介导的途径产生的。我们的发现表明，BUV的内分泌干扰作用令人担忧。

"点击查看英文标题和摘要"

Estrogenic activity of benzotriazole UV stabilizers evaluated through in vitro assays and computational studies.

Benzotriazole UV stabilizers (BUVs) are used in a variety of products to prevent yellowing and degradation. However, knowledge of the estrogenic activity of BUVs is still lacking. In the present study, a strategy combining in vitro assays and computational studies was adopted to evaluate the estrogenic activity of BUVs. 2-(2-Hydroxy-5-methlphenyl) benzotriazole (UV-P), 2-(5-tert-butyl-2-hydroxyphenyl)benzotriazole (UV-PS), and 2-(3-Allyl-2-hydroxy-5-methylphenyl)-2H-benzotriazole (UV-9) induced partial estrogenic activity while 2-(2-hydroxy-5-tert-octyl-phenyl)benzotriazole (UV-329), 2-(3-s-butyl-5-tert-butyl-2-hydroxyphenyl)benzotriazole (UV-350), and 3-(2H-benzotriazolyl)-5- (1,1-di-methylethyl)-4-hydroxy-benzene-propanoic acid octyl esters (UV-384) showed no estrogenic activity in MVLN assays. The results of in vitro assays were in accord with the results of computational studies. Moreover, ICI 182,780 suppressed the estrogenic activity of BUVs both in the absence and presence of E2, demonstrating that the estrogen responsive element (ERE) transcription activities of BUVs are generated through an estrogen receptor (ER) mediated pathway. Our findings suggest that the endocrine disruption effects of BUVs are a cause for concern.

更新日期：2020-04-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>