An efficient base-promoted reaction of O-, N-, and S-nucleophiles with 2-chloro-3,3,3-trifluoprop-1-ene (HCFO-1233xf) is described providing access to various β-substituted-trifluoromethyl-ethenes under mild reaction conditions. Mechanistic investigations shed some light on the regio-, chemo-, and stereoselectivities observed. The olefins prepared represent attractive intermediates in chemical discovery: some applications include their conversion to pyrrolidines via a [3 + 2] dipolar cycloaddition reaction. These weakly basic amines represent novel synthons that could be readily elaborated through a range of reactions.

中文翻译：

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2-氯-3,3,3-三氟丙-1-烯（HCFO-1233xf）的应用：各种β-取代的三氟甲基乙烯的快速入门。

描述了O-，N-和S-亲核试剂与2-氯-3,3,3-三氟丙-1-烯（HCFO-1233xf）的有效碱促进反应，可提供各种β-取代的三氟甲基-乙烯在温和的反应条件下。机理研究为观察到的区域选择性，化学选择性和立体选择性提供了一些启示。制备的烯烃代表了化学发现中的诱人中间体：某些应用包括通过[3 + 2]偶极环加成反应将其转化为吡咯烷。这些弱碱性胺代表了新型合成子，可以通过一系列反应轻松地进行合成。