Interactions between reinforcement history and drug‐primed reinstatement: Studies with MDPV and mixtures of MDPV and caffeine,Addiction Biology

当前位置： X-MOL 学术 › Addict. Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Interactions between reinforcement history and drug‐primed reinstatement: Studies with MDPV and mixtures of MDPV and caffeine
Addiction Biology ( IF 3.1 ) Pub Date : 2020-04-01 , DOI: 10.1111/adb.12904
Michelle R Doyle _{1,

2} , Agnieszka Sulima ₃ , Kenner C Rice ₃ , Gregory T Collins _{1,

2}

Affiliation

Many drugs of abuse are mixed with other psychoactive substances (e.g., caffeine) prior to their sale or use. Synthetic cathinones (e.g., 3,4‐methylenedioxypyrovalerone [MDPV]) are commonly mixed with caffeine or other cathinones (e.g., 3,4‐methylenedioxy‐N‐methylcathinone [methylone]), and these “bath salts” mixtures (e.g., MDPV + caffeine) can exhibit supra‐additive interactions with regard to their reinforcing and discriminative stimulus properties. However, little is known about relapse‐related effects of drug mixtures. In these studies, male Sprague–Dawley rats self‐administered 0.032 mg/kg/inf MDPV or a mixture of MDPV + caffeine (0.029 + 0.66 mg/kg/inf, respectively) and then underwent multiple rounds of extinction and reinstatement testing to evaluate the influence of reinforcement history and drug‐associated stimuli on the effectiveness of saline (drug‐paired stimuli alone), MDPV (0.032–1.0 mg/kg), caffeine (1.0–32 mg/kg), and mixtures of MDPV:caffeine (in 3:1, 1:1, and 1:3 ratios, relative to each drug's ED₅₀) to reinstate responding. Dose‐addition analyses were used to determine the nature of the drug–drug interaction for each mixture. MDPV and caffeine dose‐dependently reinstated responding and were equally effective, regardless of reinforcement history. Most fixed ratio mixtures of MDPV + caffeine exhibited supra‐additive interactions, reinstating responding to levels greater than was observed with caffeine and/or MDPV alone. Drug‐associated stimuli also played a key role in reinstating responding, especially for caffeine. Together, these results demonstrate that the composition of drug mixtures can impact relapse‐related effects of drug mixtures, and “bath salts” mixtures (MDPV + caffeine) may be more effective at promoting relapse‐related behaviors than the constituents alone. Further research is needed to determine how other polysubstance reinforcement histories can impact relapse‐related behaviors.

中文翻译：

强化历史和药物引发的恢复之间的相互作用：MDPV 和 MDPV 和咖啡因混合物的研究

许多滥用药物在销售或使用前与其他精神活性物质（例如咖啡因）混合。合成卡西酮（如 3,4-亚甲二氧基吡戊酮 [MDPV]）通常与咖啡因或其他卡西酮（如 3,4-亚甲二氧基-N-甲基卡西酮 [甲基酮]）和这些“浴盐”混合物（例如，MDPV + 咖啡因）在增强和区分刺激特性方面可以表现出超加性相互作用。然而，关于药物混合物的复发相关影响知之甚少。在这些研究中，雄性 Sprague-Dawley 大鼠自我给药 0.032 mg/kg/inf MDPV 或 MDPV + 咖啡因的混合物（分别为 0.029 + 0.66 mg/kg/inf），然后进行多轮消退和恢复测试以评估强化历史和药物相关刺激对盐水（仅药物配对刺激）、MDPV（0.032-1.0 mg/kg）、咖啡因（1.0-32 mg/kg）和 MDPV：咖啡因混合物的影响（相对于每种药物的 ED ₅₀，比例为 3:1、1:1 和 1:3) 恢复响应。剂量添加分析用于确定每种混合物的药物-药物相互作用的性质。MDPV 和咖啡因剂量依赖性地恢复反应并且同样有效，无论强化历史如何。MDPV + 咖啡因的大多数固定比例混合物表现出超加性相互作用，恢复对高于单独使用咖啡因和/或 MDPV 观察到的水平的反应。与药物相关的刺激在恢复反应方面也发挥了关键作用，尤其是对咖啡因。总之，这些结果表明药物混合物的成分会影响药物混合物的复发相关效应，并且“浴盐”混合物（MDPV + 咖啡因）可能比单独的成分更有效地促进复发相关行为。

更新日期：2020-04-01

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南