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Unique Cell Surface Mannan of Yeast Pathogen Candida auris with Selective Binding to IgG.
ACS Infectious Diseases ( IF 4.0 ) Pub Date : 2020-04-10 , DOI: 10.1021/acsinfecdis.9b00450 Lufeng Yan 1 , Ke Xia 1 , Yanlei Yu 1 , Anna Miliakos 1 , Sudha Chaturvedi 2, 3 , Fuming Zhang 1 , Shiguo Chen 1 , Vishnu Chaturvedi 2, 3 , Robert J Linhardt 1
ACS Infectious Diseases ( IF 4.0 ) Pub Date : 2020-04-10 , DOI: 10.1021/acsinfecdis.9b00450 Lufeng Yan 1 , Ke Xia 1 , Yanlei Yu 1 , Anna Miliakos 1 , Sudha Chaturvedi 2, 3 , Fuming Zhang 1 , Shiguo Chen 1 , Vishnu Chaturvedi 2, 3 , Robert J Linhardt 1
Affiliation
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The emerging, multidrug-resistant yeast pathogen Candida auris is responsible for healthcare-associated outbreaks across the globe with high mortality. The rapid spread of C. auris is linked to its successful colonization of human skin, followed by bloodstream infections. We compared glycomics and proteomics of C. auris to closely and distantly related human pathogenic yeasts, C. haemulonii and C. albicans, with the aim to understand the role of cell surface molecules in skin colonization and immune system interactions. Candida auris mannan is distinct from other pathogenic Candida species, as it is highly enriched in β-1,2-linkages. The experimental data showed that C. auris surface mannan β-1,2-linkages were important for the interactions with the immune protein IgG, found in blood and in sweat glands, and with the mannose binding lectin, found in the blood. Candida auris mannan binding to IgG was from 12- to 20-fold stronger than mannan from the more common pathogen C. albicans. The findings suggest unique C. auris mannan could be crucial for the biology and pathogenesis of this emerging pathogen.
中文翻译：
酵母病原体耳念珠菌独特的细胞表面甘露聚糖，可选择性结合 IgG。
新兴的多重耐药酵母病原体耳念珠菌是全球范围内与医疗保健相关的疫情爆发的罪魁祸首，死亡率很高。耳念珠菌的快速传播与其在人类皮肤上的成功定殖以及随后的血流感染有关。我们将耳念珠菌的糖组学和蛋白质组学与密切相关和远缘相关的人类致病酵母、血色念珠菌和白色念珠菌进行了比较，目的是了解细胞表面分子在皮肤定植和免疫系统相互作用中的作用。耳念珠菌甘露聚糖与其他致病性念珠菌物种不同，因为它富含 β-1,2-连接。实验数据表明，耳念珠菌表面甘露聚糖 β-1,2-连接对于与血液和汗腺中发现的免疫蛋白 IgG 以及血液中发现的甘露糖结合凝集素的相互作用非常重要。耳念珠菌甘露聚糖与 IgG 的结合比来自更常见病原体白色念珠菌的甘露聚糖强 12 至 20 倍。研究结果表明，独特的耳念珠菌甘露聚糖可能对这种新兴病原体的生物学和发病机制至关重要。
更新日期：2020-04-01
中文翻译：
酵母病原体耳念珠菌独特的细胞表面甘露聚糖，可选择性结合 IgG。
新兴的多重耐药酵母病原体耳念珠菌是全球范围内与医疗保健相关的疫情爆发的罪魁祸首，死亡率很高。耳念珠菌的快速传播与其在人类皮肤上的成功定殖以及随后的血流感染有关。我们将耳念珠菌的糖组学和蛋白质组学与密切相关和远缘相关的人类致病酵母、血色念珠菌和白色念珠菌进行了比较，目的是了解细胞表面分子在皮肤定植和免疫系统相互作用中的作用。耳念珠菌甘露聚糖与其他致病性念珠菌物种不同，因为它富含 β-1,2-连接。实验数据表明，耳念珠菌表面甘露聚糖 β-1,2-连接对于与血液和汗腺中发现的免疫蛋白 IgG 以及血液中发现的甘露糖结合凝集素的相互作用非常重要。耳念珠菌甘露聚糖与 IgG 的结合比来自更常见病原体白色念珠菌的甘露聚糖强 12 至 20 倍。研究结果表明，独特的耳念珠菌甘露聚糖可能对这种新兴病原体的生物学和发病机制至关重要。
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