Prostaglandin E₂ is produced in response to inflammation, often associated with human disease. As prostaglandins are rapidly metabolized, quantification of end urinary metabolites depend on chemical synthesis of isotopically labeled standards to support metabolite quantification. A concise synthesis of tetranor-PGE₁ is described including a late stage incorporation of an isotopically labeled side-chain.

中文翻译：

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四去甲-PGE1 的合成：前列腺素 E1 和 E2 的尿代谢物。

前列腺素 E ₂是因炎症反应而产生的，通常与人类疾病有关。由于前列腺素代谢迅速，最终尿代谢物的定量依赖于同位素标记标准品的化学合成来支持代谢物定量。描述了四去甲-PGE ₁的简明合成，包括同位素标记侧链的后期掺入。