Circuits and functions of the lateral habenula in health and in disease.,Nature Reviews Neuroscience

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Circuits and functions of the lateral habenula in health and in disease.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2020-04-08 , DOI: 10.1038/s41583-020-0292-4
Hailan Hu _{1,

2,

3,

4,

5} , Yihui Cui ₂ , Yan Yang ₂

Affiliation

The past decade has witnessed exponentially growing interest in the lateral habenula (LHb) owing to new discoveries relating to its critical role in regulating negatively motivated behaviour and its implication in major depression. The LHb, sometimes referred to as the brain's 'antireward centre', receives inputs from diverse limbic forebrain and basal ganglia structures, and targets essentially all midbrain neuromodulatory systems, including the noradrenergic, serotonergic and dopaminergic systems. Its unique anatomical position enables the LHb to act as a hub that integrates value-based, sensory and experience-dependent information to regulate various motivational, cognitive and motor processes. Dysfunction of the LHb may contribute to the pathophysiology of several psychiatric disorders, especially major depression. Recently, exciting progress has been made in identifying the molecular and cellular mechanisms in the LHb that underlie negative emotional state in animal models of drug withdrawal and major depression. A future challenge is to translate these advances into effective clinical treatments.

中文翻译：

健康和疾病中外侧ha管的回路和功能。

在过去的十年中，由于新的发现涉及其在调节负动机行为中的关键作用及其对严重抑郁的影响，过去人们对侧面哈氏囊（LHb）的兴趣呈指数增长。LHb有时被称为大脑的“反奖励中心”，接收来自不同的边缘前脑和基底神经节结构的输入，并且基本上针对所有中脑神经调节系统，包括去甲肾上腺素能，血清素能和多巴胺能系统。其独特的解剖位置使LHb可以充当枢纽，整合基于价值，感官和经验的信息来调节各种动机，认知和运动过程。LHb的功能障碍可能有助于某些精神疾病，特别是重度抑郁症的病理生理。最近，在确定戒断和严重抑郁动物模型中负性情绪状态基础的LHb中的分子和细胞机制方面，已经取得了令人激动的进展。未来的挑战是将这些进展转化为有效的临床治疗方法。

更新日期：2020-04-08

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